Common Name: p-Nitrosodiphenylamine CAS Number: 156-10-5 DOT Number: None Date: May, 1989 ----------------------------------------- HAZARD SUMMARY * p-Nitrosodiphenylamine can affect you when breathed in and may also enter the body through the skin. * p-Nitrosodiphenylamine should be handled as a CARCINOGEN WITH EXTREME CAUTION. * Exposure can damage the liver. This may not be readily detectable by currently available liver tests. * Contact could irritate the skin and eyes. Breathing the dust could irritate the nose, throat and possibly lungs. * Higher exposure levels could cause headache, poor appetite, weakness, aching and even jaundice. IDENTIFICATION p-Nitrosodiphenylamine is a black powder or plate like material with a bluish luster. It is used as a chemical intermediate for dyes and pharmaceuticals and in making monomers and vulcanizing rubber. REASON FOR CITATION * p-Nitrosodiphenylamine is on the Hazardous Substance List because it is cited by NTP and EPA. * This chemical is on the Special Health Hazard Substance List because it is a CARCINOGEN. * Definitions are attached. HOW TO DETERMINE IF YOU ARE BEING EXPOSED * Exposure to hazardous substances should be routinely evaluated. This may include collecting personal and area air samples. You can obtain copies of sampling results from your employer. You have a legal right to this information under OSHA 1910.20. * If you think you are experiencing any work related health problems, see a doctor trained to recognize occupational diseases. Take this Fact Sheet with you. WORKPLACE EXPOSURE LIMITS No occupational exposure limits have been established for p- Nitrosodiphenylamine. This does not mean that this substance is not harmful. Safe work practices should always be followed. It should be recognized that p-Nitrosodiphenylamine can be absorbed through your skin, thereby increasing your exposure. * p-Nitrosodiphenylamine may be a CARCINOGEN in humans. There may be no safe level of exposure to a carcinogen, so all contact should be reduced to the lowest possible level. WAYS OF REDUCING EXPOSURE * Where possible, enclose operations and use local exhaust ventilation at the site of chemical release. If local exhaust ventilation or enclosure is not used, respirators should be worn. * Wear protective work clothing. * Wash thoroughly immediately after exposure to p- Nitrosodiphenylamine and at the end of the workshift. * Post hazard and warning information in the work area. In addition, as part of an ongoing education and training effort, communicate all information on the health and safety hazards of p-Nitrosodiphenylamine to potentially exposed workers. This Fact Sheet is a summary source of information of all potential and most severe health hazards that may result from exposure. Duration of exposure, concentration of the substance and other factors will affect your susceptibility to any of the potential effects described below. ------------------------------------------ HEALTH HAZARD INFORMATION Acute Health Effects The following acute (short term) health effects may occur immediately or shortly after exposure to p-Nitrosodiphenylamine: * Exposure can damage the liver. At high exposures, jaundice could occur. At lower levels, damage is difficult to detect. * Contact could irritate the skin and eyes. Breathing the dust could irritate the nose, throat and possibly lungs. * Higher exposure levels could cause headache, weakness, poor appetite, and aching. Chronic Health Effects The following chronic (long term) health effects can occur at some time after exposure to p-Nitrosodiphenylamine and can last for months or years: Cancer Hazard * p-Nitrosodiphenylamine may be a CARCINOGEN in humans since it has been shown to cause liver cancer in animals. * Many scientists believe there is no safe level of exposure to a carcinogen. Such substances may also have the potential for causing reproductive damage in humans. Reproductive Hazard * According to the information presently available to the New Jersey Department of Health, p-Nitrosodiphenylamine has not been tested for its ability to affect reproduction. Other Long Term Effects * Repeated exposure can damage the liver. * p-Nitrosodiphenylamine can enter the brain. It is not known whether brain damage could occur. * Other effects of long term or repeated exposure are unknown. MEDICAL Medical Testing If symptoms develop or overexposure is suspected, the following may be useful: * Liver function tests. Any evaluation should include a careful history of past and present symptoms with an exam. Medical tests that look for damage already done are not a substitute for controlling exposure. Request copies of your medical testing. You have a legal right to this information under OSHA 1910.20. WORKPLACE CONTROLS AND PRACTICES Unless a less toxic chemical can be substituted for a hazardous substance, ENGINEERING CONTROLS are the most effective way of reducing exposure. The best protection is to enclose operations and/or provide local exhaust ventilation at the site of chemical release. Isolating operations can also reduce exposure. Using respirators or protective equipment is less effective than the controls mentioned above, but is sometimes necessary. In evaluating the controls present in your workplace, consider: (1) how hazardous the substance is, (2) how much of the substance is released into the workplace and (3) whether harmful skin or eye contact could occur. Special controls should be in place for highly toxic chemicals or when significant skin, eye, or breathing exposures are possible. In addition, the following control is recommended: * Where possible, automatically transfer p-Nitrosodiphenylamine from drums or other storage containers to process containers. Good WORK PRACTICES can help to reduce hazardous exposures. The following work practices are recommended: * Workers whose clothing has been contaminated by p- Nitrosodiphenylamine should change into clean clothing promptly. * Do not take contaminated work clothes home. Family members could be exposed. * Contaminated work clothes should be laundered by individuals who have been informed of the hazards of exposure to p- Nitrosodiphenylamine. * If there is the possibility of skin exposure, emergency shower facilities should be provided. * On skin contact with p-Nitrosodiphenylamine, immediately wash or shower to remove the chemical. At the end of the workshift, wash any areas of the body that may have contacted p- Nitrosodiphenylamine, whether or not known skin contact has occurred. * Do not eat, smoke, or drink where p-Nitrosodiphenylamine is handled, processed, or stored, since the chemical can be swallowed. Wash hands carefully before eating or smoking. * Use a vacuum or a wet method to reduce dust during clean up. DO NOT DRY SWEEP. * When vacuuming, a high efficiency particulate absolute (HEPA) filter should be used, not a standard shop vacuum. PERSONAL PROTECTIVE EQUIPMENT WORKPLACE CONTROLS ARE BETTER THAN PERSONAL PROTECTIVE EQUIPMENT. However, for some jobs (such as outside work, confined space entry, jobs done only once in a while, or jobs done while workplace controls are being installed), personal protective equipment may be appropriate. The following recommendations are only guidelines and may not apply to every situation. Clothing * Avoid skin contact with p-Nitrosodiphenylamine. Wear protective gloves and clothing. Safety equipment suppliers/manufacturers can provide recommendations on the most protective glove/clothing material for your operation. * All protective clothing (suits, gloves, footwear, headgear) should be clean, available each day, and put on before work. Eye Protection * Eye protection is included in the recommended respiratory protection. Respiratory Protection IMPROPER USE OF RESPIRATORS IS DANGEROUS. Such equipment should only be used if the employer has a written program that takes into account workplace conditions, requirements for worker training, respirator fit testing and medical exams, as described in OSHA 1910.134. * Engineering controls must be effective to ensure that exposure to p-Nitrosodiphenylamine does not occur. * At any exposure level, use a MSHA/NIOSH approved supplied air respirator with a full facepiece operated in the positive pressure mode or with a full facepiece, hood, or helmet in the continuous flow mode, or use a MSHA/NIOSH approved self contained breathing apparatus with a full facepiece operated in pressure demand or other positive pressure mode. Common Name: p-Nitrosodiphenylamine DOT Number: None DOT Emergency Guide code: No Citation CAS Number: 156-10-5 ---------------------------------------- Hazard rating NJDOH NFPA FLAMMABILITY Not Found Not Rated REACTIVITY Not Found Not Rated ---------------------------------------- POISONOUS GASES ARE PRODUCED IN FIRE CARCINOGEN ---------------------------------------- Hazard Rating Key: 0=minimal; 1=slight; 2=moderate; 3=serious; 4=severe FIRE HAZARDS * Use dry chemical, CO2, water spray, or foam extinguishers. * POISONOUS GASES ARE PRODUCED IN FIRE, including Nitrogen Oxides. * If employees are expected to fight fires, they must be trained and equipped as stated in OSHA 1910.156. SPILLS AND EMERGENCIES If p-Nitrosodiphenylamine is spilled, take the following steps: * Restrict persons not wearing protective equipment from area of spill until clean up is complete. * Remove all ignition sources. * Collect powdered material in the most convenient and safe manner and deposit in sealed containers. * Ventilate area after cleanup is complete. * It may be necessary to contain and dispose of p- Nitrosodiphenylamine as a HAZARDOUS WASTE. Contact your state Environmental Program for specific recommendations. ========================================== FOR LARGE SPILLS AND FIRES immediately call your fire department. ========================================== HANDLING AND STORAGE * Prior to working with p-Nitrosodiphenylamine you should be trained on its proper handling and storage. * p-Nitrosodiphenylamine is not compatible with STRONG OXIDIZERS (such as CHLORINE, BROMINE and FLUORINE). * Store in tightly closed containers in a cool, well ventilated area. FIRST AID POISON INFORMATION Eye Contact * Immediately flush with large amounts of water for at least 15 minutes, occasionally lifting upper and lower lids. Skin Contact * Quickly remove contaminated clothing. Immediately wash contaminated skin with large amounts of soap and water. Breathing * Remove the person from exposure. * Begin rescue breathing if breathing has stopped and CPR if heart action has stopped. * Transfer promptly to a medical facility. PHYSICAL DATA Water Solubility: Slightly soluble OTHER COMMONLY USED NAMES Chemical Name: Benzenamine, 4 Nitroso N Phenyl Other Names and Formulations: 4-Nitroso-N-Phenylbenzenamine; N-Phenyl-p-Nitrosoaniline; PNP. ------------------------------------------ Not intended to be copied and sold for commercial purposes. ------------------------------------------ NEW JERSEY DEPARTMENT OF HEALTH Right to Know Program CN 368, Trenton, NJ 08625 0368 ------------------------------------------ ------------------------------------------ ECOLOGICAL INFORMATION p-Nitrosodiphenylamine is a crystalline solid which may consist of either green plates with a bluish luster or steel-blue prisms or plates. It is used as an accelerator in vulcanizing processes. p- Nitrosodiphenylamine is moderately soluble in water, and may enter the aquatic environment via effluents from chemical plants where it is manufactured or used, and spills. ACUTE (SHORT-TERM) ECOLOGICAL EFFECTS Acute toxic effects may include the death of animals, birds, or fish, and death or low growth rate in plants. Acute effects are seen two to four days after animals or plants come in contact with a toxic chemical substance. Insufficient data are available to determine or estimate the acute toxicity of p-nitrosodiphenylamine to aquatic life. CHRONIC (LONG-TERM) ECOLOGICAL EFFECTS Chronic toxic effects may include shortened lifespan, reproductive problems, lower fertility, and changes in appearance or behavior. Chronic effects can be seen long after first exposure(s) to a toxic chemical. Insufficient data are available to determine or estimate the chronic toxicity of p-nitrosodiphenylamine to aquatic life. DISTRIBUTION AND PERSISTENCE IN THE ENVIRONMENT The chemical properties of p-nitrosodiphenylamine indicate that, after a sufficient amount of time, it will tend to be distributed in the environment as follows: air, 1.83%; soil, 39.63%; water, 21.47%; suspended solids, 0.06%; aquatic biota, 0.02%; sediment, 36.99%. p-Nitrosodiphenylamine will probably be moderately persistent in aquatic ecosystems. BIOACCUMULATION IN AQUATIC ORGANISMS Some substances increase in concentration, or bioaccumulate in living organisms as they breathe contaminated air, drink contaminated water, or eat contaminated food. These chemicals can become concentrated in the tissues and internal organs of animals and humans. The concentration of p-nitrosodiphenylamine in edible tissues of most aquatic species that are consumed by humans will probably be much higher than the average concentration that was present in the water in which the organisms had been living. SUPPORT DOCUMENT: AQUIRE Database, ERL-Duluth, U.S. EPA.