Common Name: 4,4'-Methylenebis (2-Chloroaniline) CAS Number: 101-14-4 DOT Number: None Date: January 31, 1986 ----------------------------------------- HAZARD SUMMARY * 4,4'-Methylenebis (2-Chloroaniline) can affect you when breathed in and by passing through your skin. * 4,4'-Methylenebis (2-Chloroaniline) is a CARCINOGEN HANDLE WITH EXTREME CAUTION. * Exposure can interfere with the ability of the blood to carry oxygen causing headaches, dizziness, nausea and a bluish color to the skin and lips. High levels can cause trouble breathing, collapse and death. * Contact can irritate the eyes. * High or repeated exposures may affect the kidneys, cause a low blood count and cause bloody urine. IDENTIFICATION 4,4'-Methylenebis (2-Chloroaniline) is found as a tan colored solid. It is used in manufacture of polyurethanes and epoxy resins. REASON FOR CITATION * 4,4'-Methylenebis (2-Chloroaniline) is on the Hazardous Substance List because it is regulated by OSHA and cited by ACGIH, NIOSH, NTP, CAG and DEP. * This chemical is on the Special Health Hazard Substance List because it is a CARCINOGEN. * Definitions are attached. HOW TO DETERMINE IF YOU ARE BEING EXPOSED * Exposure to hazardous substances should be routinely evaluated. This may include collecting personal and area air samples. You can obtain copies of sampling results from your employer. You have a legal right to this information under OSHA 1910.20. * If you think you are experiencing any work related health problems, see a doctor trained to recognize occupational diseases. Take this Fact Sheet with you. WORKPLACE EXPOSURE LIMITS OSHA: Standard formally revoked in 1975. NIOSH: The recommended airborne exposure limit is 0.003 mg/m3 averaged over a 10 hour workshift (lowest detectable level). ACGIH: The recommended airborne exposure limit is 0.22 mg/m3 averaged over an 8 hour workshift. * 4,4'-Methylenebis (2-Chloroaniline) is a PROBABLE CARCINOGEN in humans. There may be no safe level of exposure to a carcinogen, so all contact should be reduced to the lowest possible level. WAYS OF REDUCING EXPOSURE * Where possible, enclose operations and use local exhaust ventilation at the site of chemical release. If local exhaust ventilation or enclosure is not used, respirators should be worn. * A regulated, marked area should be established where 4,4'- Methylenebis (2-Chloroaniline) is handled, used, or stored. * Wear protective work clothing. * Wash thoroughly immediately after exposure to 4,4'- Methylenebis (2-Chloroaniline) and at the end of the workshift. * Post hazard and warning information in the work area. As part of an ongoing education and training effort, communicate all information on the health and safety hazards of 4,4'- Methylenebis (2-Chloroaniline) to potentially exposed workers. This Fact Sheet is a summary source of information for workers, employers and community residents. Health professionals may also find it useful. If this substance is part of a mixture, this Fact Sheet should be used along with the manufacturer supplied Material Safety Data Sheet (MSDS). HEALTH HAZARD INFORMATION Acute Health Effects The following acute (short term) health effects may occur immediately or shortly after exposure to 4,4'-Methylenebis (2- Chloroaniline): * Exposure can interfere with the ability of the blood to carry oxygen (a condition called methemoglobinemia). This can cause headaches, dizziness, nausea and a bluish color to the skin and lips. Higher levels can cause trouble breathing, collapse and even death. * Contact can irritate the eyes. Chronic Health Effects The following chronic (long term) health effects can occur at some time after exposure to 4,4'-Methylenebis (2-Chloroaniline) and can last for months or years: Cancer Hazard * 4,4'-Methylenebis (2-Chloroaniline) is a PROBABLE CARCINOGEN in humans. There is some evidence that it causes lung, liver and bladder cancer in animals. * Many scientists believe there is no safe level of exposure to a carcinogen. Such substances may also have the potential for causing reproductive damage in humans. Reproductive Hazard * According to the information presently available to the New Jersey Department of Health, 4,4'-Methylenebis (2- Chloroaniline) has not been tested for its ability to adversely affect reproduction. Other Long Term Effects * High or repeated exposures may damage the kidneys and can cause bloody urine. * 4,4'-Methylenebis (2-Chloroaniline) may cause a low blood count. MEDICAL TESTING If symptoms develop or overexposure is suspected, the following may be useful: * Blood methemoglobin level. * Complete blood count. * Kidney function tests. Any evaluation should include a careful history of past and present symptoms with an exam. Medical tests that look for damage already done are not a substitute for controlling exposure. Request copies of your medical testing. You have a legal right to this information under OSHA 1910.20. WORKPLACE CONTROLS AND PRACTICES Unless a less toxic chemical can be substituted for a hazardous substance, ENGINEERING CONTROLS are the most effective way of reducing exposure. The best protection is to enclose operations and/or provide local exhaust ventilation at the site of chemical release. Isolating operations can also reduce exposure. Using respirators or protective equipment is less effective than the controls mentioned above, but is sometimes necessary. In evaluating the controls present in your workplace, consider: (1) how hazardous the substance is, (2) how much of the substance is released into the workplace and (3) whether harmful skin or eye contact could occur. Special controls should be in place for highly toxic chemicals or when significant skin, eye, or breathing exposures are possible. In addition, the following control is recommended: * Where possible, automatically transfer 4, 4'Methylenebis (2 Chloroaniline) from drums or other storage containers to process containers. Good WORK PRACTICES can help to reduce hazardous exposures. The following work practices are recommended: * Workers whose clothing has been contaminated by 4,4'- Methylenebis (2-Chloroaniline) should change into clean clothing promptly. * Do not take contaminated work clothes home. Family members could be exposed. * Contaminated work clothes should be laundered by individuals who have been informed of the hazards of exposure to 4,4'- Methylenebis (2-Chloroaniline). * If there is the possibility of skin exposure, emergency shower facilities should be provided. * On skin contact with 4,4'-Methylenebis (2-Chloroaniline), immediately wash or shower to remove the chemical. At the end of the workshift, wash any areas of the body that may have contacted 4,4'-Methylenebis (2-Chloroaniline), whether or not known skin contact has occurred. * Do not eat, smoke, or drink where 4,4'-Methylenebis (2- Chloroaniline) is handled, processed, or stored, since the chemical can be swallowed. Wash hands carefully before eating or smoking. * Use a vacuum or a wet method to reduce dust during clean up. DO NOT DRY SWEEP. * When vacuuming, a high efficiency particulate absolute (HEPA) filter should be used, not a standard shop vacuum. PERSONAL PROTECTIVE EQUIPMENT WORKPLACE CONTROLS ARE BETTER THAN PERSONAL PROTECTIVE EQUIPMENT. However, for some jobs (such as outside work, confined space entry, jobs done only once in a while, or jobs done while workplace controls are being installed), personal protective equipment may be appropriate. The following recommendations are only guidelines and may not apply to every situation. Clothing * Avoid skin contact with 4,4'-Methylenebis (2-Chloroaniline). Wear protective gloves and clothing. Safety equipment suppliers/manufacturers can provide recommendations on the most protective glove/clothing material for your operation. * All protective clothing (suits, gloves, footwear, headgear) should be clean, available each day and put on before work. Eye Protection * Eye protection is included in the recommended respiratory protection. Respiratory Protection IMPROPER USE OF RESPIRATORS IS DANGEROUS. Such equipment should only be used if the employer has a written program that takes into account workplace conditions, requirements for worker training, respirator fit testing, and medical exams, as described in OSHA 1910.134. * At any exposure level, use a MSHA/NIOSH approved supplied air respirator with a full facepiece operated in the positive pressure mode or with a full facepiece, hood, or helmet in the continuous flow mode, or use a MSHA/NIOSH approved self contained breathing apparatus with a full facepiece operated in pressure demand or other positive pressure mode. HANDLING AND STORAGE * Prior to working with 4,4'-Methylenebis (2-Chloroaniline) you should be trained on its proper handling and storage. * 4,4'-Methylenebis (2-Chloroaniline) must be stored to avoid contact with CHEMICALLY ACTIVE METALS (such as POTASSIUM, SODIUM, MAGNESIUM and ZINC) since violent reactions occur. * Store in tightly closed containers in a cool, well ventilated area. * A regulated, marked area should be established where 4,4'- Methylenebis (2-Chloroaniline) is handled, used, or stored. Common Name: 4,4'-Methylenebis (2-Chloroaniline) DOT Number: None DOT Emergency Guide code: No Citation CAS Number: 101-14-4 ---------------------------------------- NJ DOH Hazard rating FLAMMABILITY not found REACTIVITY not found ---------------------------------------- POISONOUS GASES ARE PRODUCED IN FIRE ---------------------------------------- Hazard Rating Key: 0=minimal; 1=slight; 2=moderate; 3=serious; 4=severe FIRE HAZARDS * Use dry chemical, CO2, water spray, or foam extinguishers. * POISONOUS GASES ARE PRODUCED IN FIRE, including Chlorine and Nitrogen oxides. * If employees are expected to fight fires, they must be trained and equipped as stated in OSHA 1910.156. SPILLS AND EMERGENCIES If 4,4'-Methylenebis (2-Chloroaniline) is spilled, take the following steps: * Restrict persons not wearing protective equipment from area of spill until cleanup is complete. * Collect powdered material in the most convenient and safe manner and deposit in sealed containers. * It may be necessary to contain and dispose of 4,4'- Methylenebis (2-Chloroaniline) as a HAZARDOUS WASTE. Contact your state Environmental Program for specific recommendations. ========================================== FOR LARGE SPILLS AND FIRES immediately call your fire department. ========================================== FIRST AID POISON INFORMATION Eye Contact * Immediately flush with large amounts of water for at least 15 minutes, occasionally lifting upper and lower lids. Skin Contact * Quickly remove contaminated clothing. Immediately wash contaminated skin with large amounts of soap and water. If Symptoms Develop * Remove the person from exposure. * Begin rescue breathing if breathing has stopped and CPR if heart action has stopped. PHYSICAL DATA Vapor Pressure: Less than 0.00001 mm Hg at 68oF Water Solubility: Slightly soluble OTHER COMMONLY USED NAMES Chemical Name: Benzenamine, 4,4' Methylenebis 2 Chloro Other Names and Formulations: BOCA; Bis Amine; Cyanaset; DACPM; MOCA. ------------------------------------------ Not intended to be copied and sold for commercial purposes. ------------------------------------------ NEW JERSEY DEPARTMENT OF HEALTH Right to Know Program CN 368, Trenton, NJ 08625 0368 ----------------------------------------- ------------------------------------------ ECOLOGICAL INFORMATION 4,4'-Methylenebis (2-Chloroaniline) is a solid chemical used as a curing agent for cross-linked thermoset polymers. It may enter the environment from industrial effluents or spills. ACUTE (SHORT-TERM) ECOLOGICAL EFFECTS Acute toxic effects may include the death of animals, birds, or fish, and death or low growth rate in plants. Acute effects are seen two to four days after animals or plants come in contact with a toxic chemical substance. 4,4'-Methylenebis (2-Chloroaniline) has high acute toxicity to aquatic life. Insufficient data are available to evaluate or predict the short-term effects of 4,4'-Methylenebis (2- Chloroaniline) on plants, birds, or land animals. CHRONIC (LONG-TERM) ECOLOGICAL EFFECTS Chronic toxic effects may include shortened lifespan, reproductive problems, lower fertility, and changes in appearance or behavior. Chronic effects can be seen long after first exposure(s) to a toxic chemical. 4,4'-Methylenebis (2-Chloroaniline) has high chronic toxicity to aquatic life. Insufficient data are available to evaluate or predict the long-term effects of 4,4'-Methylenebis (2- Chloroaniline) on plants, birds, or land animals. WATER SOLUBILITY 4,4'-Methylenebis (2-Chloroaniline) is moderately soluble in water. Concentrations of between 1 to 1,000 milligrams will mix with a liter of water. DISTRIBUTION AND PERSISTENCE IN THE ENVIRONMENT 4,4'-Methylenebis (2-Chloroaniline) is moderately persistent in the environment with a half-life of between 20 to 200 days. The half- life of a pollutant is the amount of time it takes for one-half of the chemical to be degraded. The chemical properties of 4,4'- Methylenebis (2-Chloroaniline) indicate that about 43% will enter the water, 28% aquatic sediments, and 30% terrestrial soil. BIOACCUMULATION IN AQUATIC ORGANISMS Some substances increase in concentration, or bioaccumulate, in living organisms as they breathe contaminated air, drink contaminated water, or eat contaminated food. These chemicals can become concentrated in the tissues and internal organs of animals and humans. The concentration of 4,4'-Methylenebis (2-Chloroaniline) found in fish tissues is expected to be somewhat higher than the average concentration of 4,4'-Methylenebis (2-Chloroaniline) in the water from which the fish was taken. SUPPORT DOCUMENT: AQUIRE Database, ERL-Duluth, U.S. EPA.