Common Name: Acetamide CAS Number: 60-35-5 DOT Number: None Date: January, 1989 ----------------------------------------- HAZARD SUMMARY * Acetamide can affect you when breathed in and by passing through your skin. * Repeated exposure may damage the liver. * Exposure to Acetamide can irritate the eyes, nose, and throat. IDENTIFICATION Acetamide is a colorless, crystalline (sand like) material. It is used in lacquers, explosives, and soldering flux, and as a stabilizer, plasticizer and solvent. REASON FOR CITATION * Acetamide is on the Hazardous Substance List because it is cited by EPA. * Definitions are attached. HOW TO DETERMINE IF YOU ARE BEING EXPOSED * Exposure to hazardous substances should be routinely evaluated. This may include collecting personal and area air samples. You can obtain copies of sampling results from your employer. You have a legal right to this information under OSHA 1910.20. * If you think you are experiencing any work related health problems, see a doctor trained to recognize occupational diseases. Take this Fact Sheet with you. WORKPLACE EXPOSURE LIMITS No occupational exposure limits have been established for Acetamide. This does not mean that this substance is not harmful. Safe work practices should always be followed. * It should be recognized that Acetamide can be absorbed through your skin, thereby increasing your exposure. * Acetamide may be a CARCINOGEN in humans. There may be no safe level of exposure to a carcinogen, so all contact should be reduced to the lowest possible level. WAYS OF REDUCING EXPOSURE * Where possible, enclose operations and use local exhaust ventilation at the site of chemical release. If local exhaust ventilation or enclosure is not used, respirators should be worn. * Wear protective work clothing. * Wash thoroughly immediately after exposure to Acetamide and at the end of the workshift. * Post hazard and warning information in the work area. In addition, as part of an ongoing education and training effort, communicate all information on the health and safety hazards of Acetamide to potentially exposed workers. This Fact Sheet is a summary source of information of all potential and most severe health hazards that may result from exposure. Duration of exposure, concentration of the substance and other factors will affect your susceptibility to any of the potential effects described below. ------------------------------------------ HEALTH HAZARD INFORMATION Acute Health Effects The following acute (short term) health effects may occur immediately or shortly after exposure to Acetamide: * Exposure to Acetamide can irritate the eyes, nose, and throat. Chronic Health Effects The following chronic (long term) health effects can occur at some time after exposure to Acetamide and can last for months or years: Cancer Hazard * There is limited evidence that Acetamide causes cancer in animals. It may cause liver, lung and stomach cancer. * Many scientists believe there is no safe level of exposure to a carcinogen. Such substances may also have the potential for causing reproductive damage in humans. Reproductive Hazard * According to the information presently available to the New Jersey Department of Health, Acetamide has been tested and has not adversely affected reproduction. Other Long Term Effects * Repeated exposure may damage the liver. MEDICAL Medical Testing If symptoms develop or overexposure is suspected, the following may be useful: * Liver function tests. Any evaluation should include a careful history of past and present symptoms with an exam. Medical tests that look for damage already done are not a substitute for controlling exposure. Request copies of your medical testing. You have a legal right to this information under OSHA 1910.20. WORKPLACE CONTROLS AND PRACTICES Unless a less toxic chemical can be substituted for a hazardous substance, ENGINEERING CONTROLS are the most effective way of reducing exposure. The best protection is to enclose operations and/or provide local exhaust ventilation at the site of chemical release. Isolating operations can also reduce exposure. Using respirators or protective equipment is less effective than the controls mentioned above, but is sometimes necessary. In evaluating the controls present in your workplace, consider: (1) how hazardous the substance is, (2) how much of the substance is released into the workplace and (3) whether harmful skin or eye contact could occur. Special controls should be in place for highly toxic chemicals or when significant skin, eye, or breathing exposures are possible. In addition, the following control is recommended: * Where possible, automatically transfer liquid Acetamide from drums or other storage containers to process containers. Good WORK PRACTICES can help to reduce hazardous exposures. The following work practices are recommended: * Workers whose clothing has been contaminated by Acetamide should change into clean clothing promptly. * Do not take contaminated work clothes home. Family members could be exposed. * Contaminated work clothes should be laundered by individuals who have been informed of the hazards of exposure to Acetamide. * On skin contact with Acetamide, immediately wash or shower to remove the chemical. At the end of the workshift, wash any areas of the body that may have contacted Acetamide, whether or not known skin contact has occurred. * Do not eat, smoke, or drink where Acetamide is handled, processed, or stored, since the chemical can be swallowed. Wash hands carefully before eating or smoking. * Use a vacuum or a wet method to reduce dust during cleanup. DO NOT DRY SWEEP. * When vacuuming, a high efficiency particulate absolute (HEPA) filter should be used, not a standard shop vacuum. PERSONAL PROTECTIVE EQUIPMENT WORKPLACE CONTROLS ARE BETTER THAN PERSONAL PROTECTIVE EQUIPMENT. However, for some jobs (such as outside work, confined space entry, jobs done only once in a while, or jobs done while workplace controls are being installed), personal protective equipment may be appropriate. The following recommendations are only guidelines and may not apply to every situation. Clothing * Avoid skin contact with Acetamide. Wear protective gloves and clothing. Safety equipment suppliers/manufacturers can provide recommendations on the most protective glove/clothing material for your operation. * All protective clothing (suits, gloves, footwear, headgear) should be clean, available each day, and put on before work. Eye Protection * Eye protection is included in the recommended respiratory protection. Respiratory Protection IMPROPER USE OF RESPIRATORS IS DANGEROUS. Such equipment should only be used if the employer has a written program that takes into account workplace conditions, requirements for worker training, respirator fit testing and medical exams, as described in OSHA 1910.134. * Engineering controls must be effective to ensure that exposure to Acetamide does not occur. * At any exposure level, use a MSHA/NIOSH approved supplied air respirator with a full facepiece operated in the positive pressure mode or with a full facepiece, hood, or helmet in the continuous flow mode, or use a MSHA/NIOSH approved self contained breathing apparatus with a full facepiece operated in pressure demand or other positive pressure mode. Common Name: Acetamide DOT Number: None DOT Emergency Guide code: No Citation CAS Number: 60-35-5 ---------------------------------------- Hazard rating NJDOH NFPA FLAMMABILITY 1 Not Rated REACTIVITY 0 Not Rated ---------------------------------------- POISONOUS GASES ARE PRODUCED IN FIRE ---------------------------------------- Hazard Rating Key: 0=minimal; 1=slight; 2=moderate; 3=serious; 4=severe FIRE HAZARDS * Acetamide is a COMBUSTIBLE SOLID. * Use dry chemical, CO2, water spray, or foam extinguishers. * POISONOUS GASES ARE PRODUCED IN FIRE, including Nitrogen Oxide. * If employees are expected to fight fires, they must be trained and equipped as stated in OSHA 1910.156. SPILLS AND EMERGENCIES If Acetamide is spilled, take the following steps: * Restrict persons not wearing protective equipment from area of spill until clean up is complete. * Remove all ignition sources. * Collect powdered material in the most convenient and safe manner and deposit in sealed containers. * It may be necessary to contain and dispose of Acetamide as a HAZARDOUS WASTE. Contact your state Department of Environmental Protection (DEP) or your regional office of the federal Environmental Protection Agency (EPA) for specific recommendations. ========================================== FOR LARGE SPILLS AND FIRES immediately call your fire department. ========================================== HANDLING AND STORAGE * Prior to working with Acetamide you should be trained on its proper handling and storage. * Acetamide is not compatible with STRONG ACIDS (such as HYDROCHLORIC, SULFURIC and NITRIC), STRONG OXIDIZERS (such as CHLORINE, BROMINE and FLUORINE), STRONG BASES (such as SODIUM HYDROXIDE), and STRONG REDUCING AGENTS. * Store in tightly closed containers in a cool, well ventilated area. * Sources of ignition, such as smoking and open flames, are prohibited where Acetamide is used, handled, or stored in a manner that could create a potential fire or explosion hazard. FIRST AID POISON INFORMATION Eye Contact * Immediately flush with large amounts of water for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention. Skin Contact * Remove contaminated clothing. Wash contaminated skin with soap and water. Breathing * Remove the person from exposure. PHYSICAL DATA Vapor Pressure: 1 mm Hg at 149oF (65oC) Water Solubility: Soluble OTHER COMMONLY USED NAMES Other Names and Formulations: Acetimidic Acid; Ethanamide. ------------------------------------------ Not intended to be copied and sold for commercial purposes. ------------------------------------------ NEW JERSEY DEPARTMENT OF HEALTH Right to Know Program CN 368, Trenton, NJ 08625 0368 ------------------------------------------ ------------------------------------------ ECOLOGICAL INFORMATION Acetamide is a colorless crystalline solid. It is used as a general solvent for both inorganic and organic compounds, a solubilizer, a plasticizer, an antacid in the lacquer, explosives and cosmetics industries, a stabilizer in peroxides, and in the synthesis of organic chemicals such as methylamine and thioacetamide. It may enter the environment from industrial discharges or spills. ACUTE (SHORT-TERM) ECOLOGICAL EFFECTS Acute toxic effects may include the death of animals, birds, or fish, and death or low growth rate in plants. Acute effects are seen two to four days after animals or plants come in contact with a toxic chemical substance. Acetamide has slight acute toxicity to aquatic life and high acute toxicity to birds. It has caused germination decrease and size decrease in several agricultural crops. Insufficient data are available to evaluate or predict the short-term effects of acetamide to land animals. CHRONIC (LONG-TERM) ECOLOGICAL EFFECTS Chronic toxic effects may include shortened lifespan, reproductive problems, lower fertility, and changes in appearance or behavior. Chronic effects can be seen long after first exposure(s) to a toxic chemical. Acetamide has slight chronic toxicity to aquatic life. Insufficient data are available to evaluate or predict the long- term effects of acetamide to plants, birds, or land animals. WATER SOLUBILITY Acetamide is highly soluble in water. Concentrations of 1,000 milligrams and more will mix with a liter of water. DISTRIBUTION AND PERSISTENCE IN THE ENVIRONMENT Acetamide is slightly persistent in water, with a half-life of between 2 to 20 days. The half-life of a pollutant is the amount of time it takes for one-half of the chemical to be degraded. Virtually 100% of acetamide will end up in the water. BIOACCUMULATION IN AQUATIC ORGANISMS Some substances increase in concentration, or bioaccumulate, in living organisms as they breathe contaminated air, drink contaminated water, or eat contaminated food. These chemicals can become concentrated in the tissues and internal organs of animals and humans. The concentration of acetamide found in fish tissues is expected to be about the same as the average concentration of acetamide in the water from which the fish was taken. SUPPORT DOCUMENT: AQUIRE Database, ERL-Duluth, U.S. EPA.