Common Name: n-Nitrosodi-n-Propylamine CAS Number: 621-64-7 DOT Number: None Date: May, 1989 ----------------------------------------- HAZARD SUMMARY * n-Nitrosodi-n-Propylamine can affect you when breathed in and by passing through your skin. * n-Nitrosodi-n-Propylamine should be handled as a CARCINOGEN WITH EXTREME CAUTION. * Exposure to many closely related chemicals ("nitrosamines") can damage the liver. It is not known whether n-Nitrosodi-n- Propylamine also has this effect. IDENTIFICATION n-Nitrosodi-n-Propylamine is a yellow liquid. It is used for research purposes. REASON FOR CITATION * n-Nitrosodi-n-Propylamine is on the Hazardous Substance List because it is cited by NTP, CAG, IARC and EPA. * This chemical is on the Special Health Hazard Substance List because it is a CARCINOGEN. HOW TO DETERMINE IF YOU ARE BEING EXPOSED * Exposure to hazardous substances should be routinely evaluated. This may include collecting personal and area air samples. You can obtain copies of sampling results from your employer. You have a legal right to this information under OSHA 1910.20. * If you think you are experiencing any work related health problems, see a doctor trained to recognize occupational diseases. Take this Fact Sheet with you. WORKPLACE EXPOSURE LIMITS No occupational exposure limits have been established for n- Nitrosodi-n-Propylamine. This does not mean that this substance is not harmful. Safe work practices should always be followed. It should be recognized that n-Nitrosodi-n-Propylamine can be absorbed through your skin, thereby increasing your exposure. * n-Nitrosodi-n-Propylamine may be a CARCINOGEN in humans. There may be no safe level of exposure to a carcinogen, so all contact should be reduced to the lowest possible level. WAYS OF REDUCING EXPOSURE * Where possible, enclose operations and use local exhaust ventilation at the site of chemical release. If local exhaust ventilation or enclosure is not used, respirators should be worn. * Wear protective work clothing. * Wash thoroughly immediately after exposure to n-Nitrosodi-n- Propylamine and at the end of the workshift. * Post hazard and warning information in the work area. In addition, as part of an ongoing education and training effort, communicate all information on the health and safety hazards of n-Nitrosodi-n-Propylamine to potentially exposed workers. This Fact Sheet is a summary source of information of all potential and most severe health hazards that may result from exposure. Duration of exposure, concentration of the substance and other factors will affect your susceptibility to any of the potential effects described below. ------------------------------------------ HEALTH HAZARD INFORMATION Acute Health Effects The following acute (short term) health effects may occur immediately or shortly after exposure to n-Nitrosodi-n-Propylamine: * Exposure to many closely related chemicals (nitrosamines) can cause severe liver damage. It is unknown whether n-Nitrosodi- n-Propylamine causes this effects. Liver symptoms usually only occur when damage is more severe. Symptoms can include fatigue, poor appetite, reduced desire for cigarettes (in smokers), and in more severe cases, jaundice. Chronic Health Effects The following chronic (long term) health effects can occur at some time after exposure to n-Nitrosodi-n-Propylamine and can last for months or years: Cancer Hazard * n-Nitrosodi-n-Propylamine may be a CARCINOGEN in humans since it has been shown to cause liver, kidney and respiratory tract cancer in animals. * Many scientists believe there is no safe level of exposure to a carcinogen. Such substances may also have the potential for causing reproductive damage in humans. Reproductive Hazard * According to the information presently available to the New Jersey Department of Health, n-Nitrosodi-n-Propylamine has not been tested for its ability to adversely affect reproduction. Other Long Term Effects * Repeated exposure to many closely related chemicals (nitrosamines) can damage the liver. This can cause permanent damage with a shrunken liver (cirrbrosis). It is not known whether n-Nitrosodi-n-Propylamine has this effect. * Other effects of repeated exposure are unknown. MEDICAL Medical Testing If symptoms develop or overexposure is suspected, the following may be useful: * Liver function tests (these can underestimate damage unless done within a few days after exposure). Any evaluation should include a careful history of past and present symptoms with an exam. Medical tests that look for damage already done are not a substitute for controlling exposure. Request copies of your medical testing. You have a legal right to this information under OSHA 1910.20. Mixed Exposures * Because smoking can cause heart disease, as well as lung cancer, emphysema, and other respiratory problems, it may worsen respiratory conditions caused by chemical exposure. Even if you have smoked for a long time, stopping now will reduce your risk of developing health problems. * Tobacco smoke can release similar chemicals and could add to total exposure. WORKPLACE CONTROLS AND PRACTICES Unless a less toxic chemical can be substituted for a hazardous substance, ENGINEERING CONTROLS are the most effective way of reducing exposure. The best protection is to enclose operations and/or provide local exhaust ventilation at the site of chemical release. Isolating operations can also reduce exposure. Using respirators or protective equipment is less effective than the controls mentioned above, but is sometimes necessary. (3) whether harmful skin or eye contact could occur. Special controls should be in place for highly toxic chemicals or when significant skin, eye, or breathing exposures are possible. In addition, the following control is recommended: * Where possible, automatically pump liquid n-Nitrosodi-n- Propylamine from drums or other storage containers to process containers. Good WORK PRACTICES can help to reduce hazardous exposures. The following work practices are recommended: * Workers whose clothing has been contaminated by n-Nitrosodi-n- Propylamine should change into clean clothing promptly. * Do not take contaminated work clothes home. Family members could be exposed. * Contaminated work clothes should be laundered by individuals who have been informed of the hazards of exposure to n- Nitrosodi-n-Propylamine. * On skin contact with n-Nitrosodi-n-Propylamine, immediately wash or shower to remove the chemical. At the end of the workshift, wash any areas of the body that may have contacted n-Nitrosodi-n-Propylamine, whether or not known skin contact has occurred. * Do not eat, smoke, or drink where n-Nitrosodi-n-Propylamine is handled, processed, or stored, since the chemical can be swallowed. Wash hands carefully before eating or smoking. PERSONAL PROTECTIVE EQUIPMENT WORKPLACE CONTROLS ARE BETTER THAN PERSONAL PROTECTIVE EQUIPMENT. However, for some jobs (such as outside work, confined space entry, jobs done only once in a while, or jobs done while workplace controls are being installed), personal protective equipment may be appropriate. The following recommendations are only guidelines and may not apply to every situation. Clothing * Avoid skin contact with n-Nitrosodi-n-Propylamine. Wear protective gloves and clothing. Safety equipment suppliers/manufacturers can provide recommendations on the most protective glove/clothing material for your operation. * All protective clothing (suits, gloves, footwear, headgear) should be clean, available each day, and put on before work. Eye Protection * Eye protection is included in the recommended respiratory protection. Respiratory Protection IMPROPER USE OF RESPIRATORS IS DANGEROUS. Such equipment should only be used if the employer has a written program that takes into account workplace conditions, requirements for worker training, respirator fit testing and medical exams, as described in OSHA 1910.134. * Engineering controls must be effective to ensure that exposure to n-Nitrosodi-n-Propylamine does not occur. * At any exposure level, use a MSHA/NIOSH approved supplied air respirator with a full facepiece operated in the positive pressure mode or with a full facepiece, hood, or helmet in the continuous flow mode, or use a MSHA/NIOSH approved self contained breathing apparatus with a full facepiece operated in pressure demand or other positive pressure mode. Common Name: n-Nitrosodi-n-Propylamine DOT Number: None DOT Emergency Guide code: No Citation CAS Number: 621-64-7 ---------------------------------------- Hazard rating NJ DOH NFPA FLAMMABILITY 1 No Rating REACTIVITY 0 No Rating ---------------------------------------- CARCINOGEN POISONOUS GASES ARE PRODUCED IN FIRE ---------------------------------------- Hazard Rating Key: 0=minimal; 1=slight; 2=moderate; 3=serious; 4=severe FIRE HAZARDS * Use dry chemical, CO2, water spray, or foam extinguishers. * POISONOUS GASES ARE PRODUCED IN FIRE, including Nitrogen Oxides. * If employees are expected to fight fires, they must be trained and equipped as stated in OSHA 1910.156. SPILLS AND EMERGENCIES If n-Nitrosodi-n-Propylamine is spilled or leaked, take the following steps: * Restrict persons not wearing protective equipment from area of spill or leak until cleanup is complete. * Remove all ignition sources. * Ventilate area of spill or leak. * Absorb liquids in vermiculite, dry sand, earth, or a similar material and deposit in sealed containers. * It may be necessary to contain and dispose of n-Nitrosodi-n- Propylamine as a HAZARDOUS WASTE. Contact your state Environmental Program for specific recommendations. ========================================== FOR LARGE SPILLS AND FIRES immediately call your fire department. ========================================== HANDLING AND STORAGE * Prior to working with n-Nitrosodi-n-Propylamine you should be trained on its proper handling and storage. * n-Nitrosodi-n-Propylamine is not compatible with Copper Salts, Mercury Salts, Strong Mineral Acids and Strong Oxidants. * Store in tightly closed containers in a cool, well ventilated area. FIRST AID POISON INFORMATION Eye Contact * Immediately flush with large amounts of water for at least 15 minutes, occasionally lifting upper and lower lids. Skin Contact * Quickly remove contaminated clothing. Immediately wash contaminated skin with large amounts of water. Breathing * Remove the person from exposure. * Begin rescue breathing if breathing has stopped and CPR if heart action has stopped. * Transfer promptly to a medical facility. PHYSICAL DATA Flash Point: 210oF (98oC) Water Solubility: Soluble OTHER COMMONLY USED NAMES Chemical Name: 1 Propanamine, N Nitroso N Propyl Other Names and Formulations: Di n propylnitrosamine; DPNA; NDPA; N Nitrosodipropylamine. ------------------------------------------ Not intended to be copied and sold for commercial purposes. ------------------------------------------ NEW JERSEY DEPARTMENT OF HEALTH Right to Know Program CN 368, Trenton, NJ 08625 0368 ------------------------------------------ ------------------------------------------ ECOLOGICAL INFORMATION n-Nitrosodi-n-Propylamine is one of a group of organic chemicals known as N-Nitrosamines which are used as synthetic intermediates or as solvents in chemical manufacture. n-Nitrosodi-n-Propylamine most likely enters the environment from industrial discharges or spills. ACUTE (SHORT-TERM) ECOLOGICAL EFFECTS Acute toxic effects may include the death of animals, birds, or fish, and death or low growth rate in plants. Acute effects are seen two to four days after animals or plants come in contact with a toxic chemical substance. Insufficient data are available to evaluate or predict the acute, short-term effects of n-Nitrosodi-n-Propylamine to aquatic life, plants, birds, or land animals. CHRONIC (LONG-TERM) ECOLOGICAL EFFECTS Chronic toxic effects may include shortened lifespan, reproductive problems, lower fertility, and changes in appearance or behavior. Chronic effects can be seen long after first exposure(s) to a toxic chemical. Insufficient data are available to evaluate or predict the chronic, long-term effects of n-Nitrosodi-n-Propylamine to aquatic life, plants, birds, or land animals. WATER SOLUBILITY n-Nitrosodi-n-Propylamine is highly soluble in water. Concentrations of 1,000 milligrams and more will mix with a liter of water. DISTRIBUTION AND PERSISTENCE IN THE ENVIRONMENT n-Nitrosodi-n-Propylamine is non-persistent in water, with a half- life, due to volatilization, of less than 2 days. The half-life of a pollutant is the amount of time it takes for one-half of the chemical to be degraded. About 54.4% of n-Nitrosodi-n-Propylamine will eventually end up in air; about 45.4% will end up in water; and the rest will end up in equal amounts in terrestrial soils and in aquatic sediments. BIOACCUMULATION IN AQUATIC ORGANISMS Some substances increase in concentration, or bioaccumulate, in living organisms as they breathe contaminated air, drink contaminated water, or eat contaminated food. These chemicals can become concentrated in the tissues and internal organs of animals and humans. The concentration of n-Nitrosodi-n-Propylamine found in fish tissues is expected to be about the same as the average concentration of n-Nitrosodi-n-Propylamine in the water from which the fish was taken. SUPPORT DOCUMENT: AQUIRE Database, ERL-Duluth, U.S. EPA.