Common Name: Dimethylcarbamoyl Chloride CAS Number: 79-44-7 DOT Number: UN 2262 Date: October 30, 1986 ----------------------------------------- HAZARD SUMMARY * Dimethylcarbamoyl Chloride can affect you when breathed in. * Dimethylcarbamoyl Chloride is a CARCINOGEN--HANDLE WITH EXTREME CAUTION. * Exposure can irritate the skin and eyes. * Breathing Dimethylcarbamoyl Chloride can irritate the nose, throat and lungs. * Exposure may cause liver damage. IDENTIFICATION Dimethylcarbamoyl Chloride is a liquid. It is used in the manufacture of pesticides and pharmaceuticals. REASON FOR CITATION * Dimethylcarbamoyl Chloride is on the RTK Hazardous Substance List because it is cited by ACGIH, IARC, DOT and other authorities. * This chemical is on the Special Health Hazard Substance List because it is a CARCINOGEN and a MUTAGEN. HOW TO DETERMINE IF YOU ARE BEING EXPOSED * Exposure to hazardous substances should be routinely evaluated. This may include collecting personal and area air samples. You can obtain copies of sampling results from your employer. You have a legal right to this information under OSHA 1910.20. * If you think you are experiencing any work-related health problems, see a doctor trained to recognize occupational diseases. Take this Fact Sheet with you. ----------------------------------------- WORKPLACE EXPOSURE LIMITS * Dimethylcarbamoyl Chloride is a PROBABLE CARCINOGEN, and the ACGIH has not set a safe exposure level for it. * There may be no safe level of exposure to a carcinogen, so all contact should be reduced to the lowest possible level. WAYS OF REDUCING EXPOSURE * Where possible, enclose operations and use local exhaust ventilation at the site of chemical release. If local exhaust ventilation or enclosure is not used, respirators should be worn. * Wear protective work clothing. * Wash thoroughly immediately after exposure to Dimethylcarbamoyl Chloride. * Post hazard and warning information in the work area. In addition, as part of an ongoing education and training effort, communicate all information on the health and safety hazards of Dimethylcarbamoyl Chloride to potentially exposed workers. This Fact Sheet is a summary source of information of all potential and most severe health hazards that may result from exposure. Duration of exposure, concentration of the substance and other factors will affect your susceptibility to any of the potential effects described below. ------------------------------------------ HEALTH HAZARD INFORMATION Acute Health Effects The following acute (short-term) health effects may occur immediately or shortly after exposure to Dimethylcarbamoyl Chloride: * Exposure, either to vapor or by splash, can irritate and inflame the eyes, leading to possible permanent damage. * Breathing Dimethylcarbamoyl Chloride can irritate the nose, throat and lungs. * Contact can irritate the skin. Chronic Health Effects The following chronic (long-term) health effects can occur at some time after exposure to Dimethylcarbamoyl Chloride and can last for months or years: Cancer Hazard * Dimethylcarbamoyl Chloride may be a CARCINOGEN in humans since it has been shown to cause cancer of the skin, lung and nose in animals. * Many scientists believe there is no safe level of exposure to a carcinogen. Such substances may also have the potential for causing reproductive damage in humans. Reproductive Hazard * According to the information presently available to the New Jersey Department of Health, Dimethylcarbamoyl Chloride has not been tested for its ability to adversely affect reproduction. Other Long-Term Effects * Prolonged contact may damage the skin and eyes. * Repeated exposure may damage the liver and lungs. MEDICAL Medical Testing Before beginning employment and at regular times after that, the following are recommended: * Lung function tests. If symptoms develop or overexposure is suspected, the following may be useful: * Liver function tests. * Exposed workers should check their skin from time to time for new growths, changes in moles and sores that won't heal. In case skin cancer occurs, it is usually easily cured when treated promptly. Any evaluation should include a careful history of past and present symptoms with an exam. Medical tests that look for damage already done are not a substitute for controlling exposure. Request copies of your medical testing. You have a legal right to this information under OSHA 1910.20. Mixed Exposures Because smoking can cause heart disease, as well as lung cancer, emphysema, and other respiratory problems, it may worsen respiratory conditions caused by chemical exposure. Even if you have smoked for a long time, stopping now will reduce your risk of developing health problems. WORKPLACE CONTROLS AND PRACTICES Unless a less toxic chemical can be substituted for a hazardous substance, ENGINEERING CONTROLS are the most effective way of reducing exposure. The best protection is to enclose operations and/or provide local exhaust ventilation at the site of chemical release. Isolating operations can also reduce exposure. Using respirators or protective equipment is less effective than the controls mentioned above, but is sometimes necessary. In evaluating the controls present in your workplace, consider: (1) how hazardous the substance is, (2) how much of the substance is released into the workplace and (3) whether harmful skin or eye contact could occur. Special controls should be in place for highly toxic chemicals or when significant skin, eye, or breathing exposures are possible. In addition, the following control is recommended: * Where possible, automatically pump liquid Dimethylcarbamoyl Chloride from drums or other storage containers to process containers. Good WORK PRACTICES can help to reduce hazardous exposures. The following work practices are recommended: * Workers whose clothing has been contaminated by Dimethylcarbamoyl Chloride should change into clean clothing promptly. * Contaminated work clothes should be laundered by individuals who have been informed of the hazards of exposure to Dimethylcarbamoyl Chloride. * Eye wash fountains should be provided in the immediate work area for emergency use. * On skin contact with Dimethylcarbamoyl Chloride, immediately wash or shower to remove the chemical. At the end of the workshift, wash any areas of the body that may have contacted Dimethylcarbamoyl Chloride, whether or not known skin contact has occur red. * Do not eat, smoke, or drink where Dimethylcarbamoyl Chloride is handled, processed, or stored, since the chemical can be swallowed. Wash hands carefully before eating or smoking. PERSONAL PROTECTIVE EQUIPMENT WORKPLACE CONTROLS ARE BETTER THAN PERSONAL PROTECTIVE EQUIPMENT. However, for some jobs (such as outside work, confined space entry, jobs done only once in a while, or jobs done while workplace controls are being installed), personal protective equipment may be appropriate. The following recommendations are only guidelines and may not apply to every situation. Clothing * Avoid skin contact with Dimethylcarbamoyl Chloride. Wear protective gloves and clothing. Safety equipment suppliers/manufacturers can provide recommendations on the most protective glove/clothing material for your operation. * All protective clothing (suits, gloves, footwear, headgear) should be clean, available each day and put on before work. Eye Protection * Eye protection is included in the recommended respiratory protection. Respiratory Protection IMPROPER USE OF RESPIRATORS IS DANGEROUS. Such equipment should only be used if the employer has a written program that takes into account workplace conditions, requirements for worker training, respirator fit testing and medical exams, as described in OSHA 1910.134. * At any exposure level, use a MSHA/NIOSH approved supplied-air respirator with a full facepiece operated in the positive pressure mode or with a full facepiece, hood, or use a MSHA/NIOSH approved self-contained breathing apparatus with a full facepiece operated in pressure-demand or other positive pressure mode. Common Name: Dimethylcarbamoyl Chloride DOT Number: UN 2262 DOT Emergency Guide code: 60 CAS Number: 79-44-7 ---------------------------------------- NJ DOH Hazard rating FLAMMABILITY Not Found REACTIVITY Not Found ---------------------------------------- MAY BURN REACTS WITH WATER POISONOUS GAS IS PRODUCED IN FIRE ---------------------------------------- Hazard Rating Key: 0=minimal; 1=slight; 2=moderate; 3=serious; 4=severe FIRE HAZARDS * Dimethylcarbamoyl Chloride may burn, but does not readily ignite. * POISONOUS GAS IS PRODUCED IN FIRE. * Use dry chemical, CO2, or foam extinguishers. * Dimethylcarbamoyl Chloride reacts with water and produces Hydrogen Chloride fumes which are TOXIC and CORROSIVE. * If employees are expected to fight fires, they must be trained and equipped as stated in OSHA 1910.156. SPILLS AND EMERGENCIES If Dimethylcarbamoyl Chloride is spilled or leaked, take the following steps: * Restrict persons not wearing protective equipment from areas of spills or leaks until clean-up is complete. * Absorb liquids in vermiculite, dry sand, earth, or a similar material and deposit in sealed containers. * It may be necessary to contain and dispose of Dimethylcarbamoyl Chloride as a HAZARDOUS WASTE. Contact your Department of Environmental Protection (DEP) or your regional office of the federal Environmental Protection Agency (EPA) for specific recommendations. ========================================== FOR LARGE SPILLS AND FIRES immediately call your fire department. ========================================== HANDLING AND STORAGE * Prior to working with Dimethylcarbamoyl Chloride you should be trained on its proper handling and storage. * Dimethylcarbamoyl Chloride must be stored to avoid contact with WATER since violent reactions occur. * Store in tightly closed containers in a cool, well-ventilated area. FIRST AID Eye Contact * Immediately flush with large amounts of water. Continue without stopping for at least 30 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. Skin Contact * Quickly remove contaminated clothing. Immediately wash contaminated skin with large amounts of soap and water. Breathing * Remove the person from exposure. * Begin rescue breathing if breathing has stopped and CPR if heart action has stopped. * Transfer promptly to a medical facility. PHYSICAL DATA Water Solubility: Insoluble OTHER COMMONLY USED NAMES Chemical Name: Carbamic Chloride, Di-methyl Other Names and Formulations: n-n-Dimethylcarbamyl Chloride; Dimethylcarbamic Acid Chloride. ------------------------------------------ Not intended to be copied and sold for commercial purposes. ------------------------------------------ NEW JERSEY DEPARTMENT OF HEALTH Right to Know Program CN 368, Trenton, NJ 08625-0368 ------------------------------------------ ------------------------------------------ ECOLOGICAL INFORMATION Dimethylcarbamoyl chloride is used as a solvent for organic chemical reactions. It serves as an intermediate in the processing of fluorinated urethanes and to make certain pesticides. It may enter the environment from industrial effluents and spills. ACUTE (SHORT-TERM) ECOLOGICAL EFFECTS Acute toxic effects may include the death of animals, birds, or fish, and death or low growth rate in plants. Acute effects are seen two to four days after animals or plants come in contact with a toxic chemical substance. Insufficient data are available to evaluate or predict the acute (short-term) effects of dimethylcarbamoyl chloride to aquatic life, plants, birds, or land animals. CHRONIC (LONG-TERM) ECOLOGICAL EFFECTS Chronic toxic effects may include shortened lifespan, reproductive problems, lower fertility, and changes in appearance or behavior. Chronic effects can be seen long after first exposure(s) to a toxic chemical. Insufficient data are available to evaluate or predict the chronic (long-term) effects of dimethylcarbamoyl chloride to aquatic life, plants, birds, or land animals. WATER SOLUBILITY Dimethylcarbamoyl chloride is slightly soluble in water. Concentrations of less than 1 milligram will mix with a liter of water. BIOACCUMULATION IN AQUATIC ORGANISMS Some substances increase in concentration, or bioaccumulate, in living organisms as they breathe contaminated air, drink contaminated water, or eat contaminated food. These chemicals can become concentrated in the tissues and internal organs of animals and humans. Dimethylcarbamoyl chloride will react rapidly with water and therefore will not accumulate in aquatic organisms or the environment. SUPPORT DOCUMENT: AQUIRE Database, ERL-Duluth, U.S. EPA.