Common Name: Quintozene CAS Number: 82-68-8 DOT Number: UN 2588 Date: May, 1989 ----------------------------------------- HAZARD SUMMARY * Quintozene can affect you when breathed in. * Quintozene should be handled as a CARCINOGEN WITH EXTREME CAUTION. * Overexposure may damage the liver and kidneys. Very high exposures may interfere with the blood's ability to carry oxygen (methemoglobinemia), causing a blue skin color. * Repeated or prolonged skin contact may lead to skin allergy. If allergy develops, even low future exposures can cause rash. * Eye contact can cause damage. IDENTIFICATION Quintozene is a colorless to cream colored crystalline (sugar or sand like) material with a musty odor. It is used as a fungicide for seed and soil treatment and for slime control in industrial water. REASON FOR CITATION * Quintozene is on the Hazardous Substance List because it is cited by CAG, DEP, DOT and EPA. * This chemical is on the Special Health Hazard Substance List because it is a CARCINOGEN. * Definitions are attached. HOW TO DETERMINE IF YOU ARE BEING EXPOSED * Exposure to hazardous substances should be routinely evaluated. This may include collecting personal and area air samples. You can obtain copies of sampling results from your employer. You have a legal right to this information under OSHA 1910.20. * If you think you are experiencing any work related health problems, see a doctor trained to recognize occupational diseases. Take this Fact Sheet with you. WORKPLACE EXPOSURE LIMITS No occupational exposure limits have been established for Quintozene. This does not mean that this substance is not harmful. Safe work practices should always be followed. * Quintozene may be a CARCINOGEN in humans. There may be no safe level of exposure to a carcinogen, so all contact should be reduced to the lowest possible level. WAYS OF REDUCING EXPOSURE * Where possible, enclose operations and use local exhaust ventilation at the site of chemical release. If local exhaust ventilation or enclosure is not used, respirators should be worn. * Wear protective work clothing. * Wash thoroughly immediately after exposure to Quintozene and at the end of the workshift. * Post hazard and warning information in the work area. In addition, as part of an ongoing education and training effort, communicate all information on the health and safety hazards of Quintozene to potentially exposed workers. This Fact Sheet is a summary source of information of all potential and most severe health hazards that may result from exposure. Duration of exposure, concentration of the substance and other factors will affect your susceptibility to any of the potential effects described below. ------------------------------------------ HEALTH HAZARD INFORMATION Acute Health Effects The following acute (short term) health effects may occur immediately or shortly after exposure to Quintozene: * Very high exposures may interfere with the blood's ability to carry oxygen to body organs and create a blue color to skin and lips (metheglobimemia). * Overexposures can damage the liver and kidneys. * Eye contact can injure the cornea of the eyes, affecting vision. Chronic Health Effects The following chronic (long term) health effects can occur at some time after exposure to Quintozene and can last for months or years: Cancer Hazard * Quintozene may be a CARCINOGEN in humans since it has been shown to cause liver cancer in animals. * Many scientists believe there is no safe level of exposure to a carcinogen. Such substances may also have the potential for causing reproductive damage in humans. Reproductive Hazard * There is limited evidence that Quintozene is a teratogen in animals. Until further testing has been done, it should be treated as a possible teratogen in humans. Other Long Term Effects * Repeated exposures may damage the liver and kidneys. Low level repeated damage may be difficult to detect with routine testing. * Prolonged or repeated skin contact can lead to development of a skin allergy. If allergy occurs, even low future exposures can cause rash and itching. Rash may also occur from the irritation or drying effect of Quintozene. MEDICAL Medical Testing If symptoms develop or overexposure is suspected, the following may be useful: * Liver and kidney function tests. * Consider Methemoglobin test after suspected high exposure. * Evaluation by a qualified allergist, including careful exposure history and special testing, may help diagnose skin allergy. Any evaluation should include a careful history of past and present symptoms with an exam. Medical tests that look for damage already done are not a substitute for controlling exposure. Request copies of your medical testing. You have a legal right to this information under OSHA 1910.20. Mixed Exposures Because more than light alcohol consumption can cause liver damage, drinking alcohol may increase the liver damage caused by Quintozene. WORKPLACE CONTROLS AND PRACTICES Unless a less toxic chemical can be substituted for a hazardous substance, ENGINEERING CONTROLS are the most effective way of reducing exposure. The best protection is to enclose operations and/or provide local exhaust ventilation at the site of chemical release. Isolating operations can also reduce exposure. Using respirators or protective equipment is less effective than the controls mentioned above, but is sometimes necessary. In evaluating the controls present in your workplace, consider: (1) how hazardous the substance is, (2) how much of the substance is released into the workplace and (3) whether harmful skin or eye contact could occur. Special controls should be in place for highly toxic chemicals or when significant skin, eye, or breathing exposures are possible. In addition, the following control is recommended: * Where possible, transfer Quintozene from drums or other storage containers to process containers. Good WORK PRACTICES can help to reduce hazardous exposures. The following work practices are recommended: * Workers whose clothing has been contaminated by Quintozene should change into clean clothing promptly. * Contaminated work clothes should be laundered by individuals who have been informed of the hazards of exposure to Quintozene. * Eye wash fountains should be provided in the immediate work area for emergency use. * On skin contact with Quintozene, immediately wash or shower to remove the chemical. At the end of the workshift, wash any areas of the body that may have contacted Quintozene, whether or not known skin contact has occurred. * Do not eat, smoke, or drink where Quintozene is handled, processed, or stored, since the chemical can be swallowed. Wash hands carefully before eating or smoking. * Use a vacuum or a wet method to reduce dust during clean up. DO NOT DRY SWEEP. * When vacuuming, a high efficiency particulate absolute (HEPA) filter should be used, not a standard shop vacuum. PERSONAL PROTECTIVE EQUIPMENT WORKPLACE CONTROLS ARE BETTER THAN PERSONAL PROTECTIVE EQUIPMENT. However, for some jobs (such as outside work, confined space entry, jobs done only once in a while, or jobs done while workplace controls are being installed), personal protective equipment may be appropriate. The following recommendations are only guidelines and may not apply to every situation. Clothing * Avoid skin contact with Quintozene. Wear protective gloves and clothing. Safety equipment suppliers/manufacturers can provide recommendations on the most protective glove/clothing material for your operation. * All protective clothing (suits, gloves, footwear, headgear) should be clean, available each day, and put on before work. Eye Protection * Wear dust proof goggles when working with powders or dust, unless full face piece respiratory protection is worn. Respiratory Protection IMPROPER USE OF RESPIRATORS IS DANGEROUS. Such equipment should only be used if the employer has a written program that takes into account workplace conditions, requirements for worker training, respirator fit testing and medical exams, as described in OSHA 1910.134. * Engineering controls must be effective to ensure that exposure to Quintozene does not occur. * Where the potential exists for exposure to Quintozene, use a MSHA/NIOSH approved supplied air respirator with a full facepiece operated in the positive pressure mode or with a full facepiece, hood, or helmet in the continuous flow mode, or use a MSHA/NIOSH approved self contained breathing apparatus with a full facepiece operated in pressure demand or other positive pressure mode. Common Name: Quintozene DOT Number: UN 2588 DOT Emergency Guide code: 53 CAS Number: 82-68-8 ---------------------------------------- Hazard rating NJ DOH NFPA FLAMMABILITY Not Found Not Rate REACTIVITY Not Found Not Rated ---------------------------------------- POISONOUS GASES ARE PRODUCED IN FIRE ---------------------------------------- Hazard Rating Key: 0=minimal; 1=slight; 2=moderate; 3=serious; 4=severe FIRE HAZARDS * Quintozene may burn, but does not readily ignite. * Use dry chemical, CO2, water spray, or foam extinguishers. * POISONOUS GASES ARE PRODUCED IN FIRE, including Chlorides and Nitrogen Oxides. * If employees are expected to fight fires, they must be trained and equipped as stated in OSHA 1910.156. SPILLS AND EMERGENCIES If Quintozene is spilled, take the following steps: * Restrict persons not wearing protective equipment from area of spill or leak until cleanup is complete. * Collect powdered material in the most convenient and safe manner and deposit in sealed containers. * It may be necessary to contain and dispose of Quintozene as a HAZARDOUS WASTE. Contact your state Environmental Program for specific recommendations. ========================================== FOR LARGE SPILLS AND FIRES immediately call your fire department. ========================================== HANDLING AND STORAGE * Prior to working with Quintozene you should be trained on its proper handling and storage. * Store in tightly closed containers in a cool, well ventilated area. FIRST AID POISON INFORMATION Eye Contact * Immediately flush with large amounts of water for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. Skin Contact * Remove contaminated clothing. Wash contaminated skin with soap and water. Breathing * Remove the person from exposure. PHYSICAL DATA Vapor Pressure: 0.0133 mmhg at 77oF (25oC) Water Solubility: Insoluble OTHER COMMONLY USED NAMES Chemical Name: Benzene, Pentachloronitro Other Names and Formulations: Pentachloronitrobenzene; PCNB; Avical; Eorthcicle; Fortox; Kobu; Marison Forte; PKHNB; Terrafun; Tri PCNB. ------------------------------------------ Not intended to be copied and sold for commercial purposes. ------------------------------------------ NEW JERSEY DEPARTMENT OF HEALTH Right to Know Program CN 368, Trenton, NJ 08625 0368 ------------------------------------------ ------------------------------------------ GENERAL INFORMATION Quintozene is a crystalline solid which is used as a fungicide for the treatment of soil and seeds. Quintozene may enter the environment from industrial discharges, agricultural run-off, or spills. ACUTE (SHORT-TERM) ECOLOGICAL EFFECTS Acute toxic effects may include the death of animals, birds, or fish, and death or low growth rate in plants. Acute effects are seen two to four days after animals or plants come in contact with a toxic chemical substance. Quintozene has high acute toxicity to aquatic life. It has caused injuries of various kinds to several agricultural crops. Insufficient data are available to evaluate or predict the short- term effects of Quintozene to birds or land animals. CHRONIC (LONG-TERM) ECOLOGICAL EFFECTS Chronic toxic effects may include shortened lifespan, reproductive problems, lower fertility, and changes in appearance or behavior. Chronic effects can be seen long after first exposure(s) to a toxic chemical Quintozene has high chronic toxicity to aquatic life. Insufficient data are available to evaluate or predict the long-term effects of Quintozene to plants, birds, or land animals. WATER SOLUBILITY Quintozene is slightly soluble in water. Concentrations of 1 milligram or less will mix with a liter of water. DISTRIBUTION AND PERSISTENCE IN THE ENVIRONMENT Quintozene is moderately persistent in water, with a half-life of between 20 to 200 days. The half-life of a pollutant is the amount of time it takes for one-half of the chemical to be degraded. About 47.6% of Quintozene will eventually end up in terrestrial soils; about 44.5% will end up in aquatic sediments; and the rest will end up in water. BIOACCUMULATION IN AQUATIC ORGANISMS Some substances increase in concentration, or bioaccumulate, in living organisms as they breathe contaminated air, drink contaminated water, or eat contaminated food. These chemicals can become concentrated in the tissues and internal organs of animals and humans. The concentration of Quintozene found in fish tissues is expected to be much higher than the average concentration of Quintozene in the water from which the fish was taken. SUPPORT DOCUMENT: ACQUIRE Database, ERL-Duluth, U.S. EPA, Phytotox