Common Name: Quinoline CAS Number: 91-22-5 DOT Number: UN 2656 Date: June 10, 1988 ----------------------------------------- HAZARD SUMMARY * Quinoline can affect you when breathed in and by passing through your skin. * Because this is a MUTAGEN, handle it as a possible cancer causing substance WITH EXTREME CAUTION. * Single high or repeated lower exposure may damage the liver and can damage the retina of the eye, affecting vision. * Skin or eye contact can cause burns. * The vapor can irritate the eyes, nose, throat and bronchial tubes and may cause sore throat, nose bleeds, hoarseness, cough, phlegm and tightness in the chest. * High exposures can cause nausea, vomiting, dizziness, trouble breathing and even death. IDENTIFICATION Quinoline is a clear, colorless liquid. It is used in pharmaceuticals, as a solvent, and to make dyes, paints and other chemicals. REASON FOR CITATION * Quinoline is on the Hazardous Substance List because it is cited by DOT, DEP, NFPA and EPA. * This chemical is on the Special Health Hazard Substance List because it is a MUTAGEN. * Definitions are attached. HOW TO DETERMINE IF YOU ARE BEING EXPOSED * Exposure to hazardous substances should be routinely evaluated. This may include collecting personal and area air samples. You can obtain copies of sampling results from your employer. You have a legal right to this information under OSHA 1910.20. * If you think you are experiencing any work related health problems, see a doctor trained to recognize occupational diseases. Take this Fact Sheet with you. WORKPLACE EXPOSURE LIMITS No occupational exposure limits have been established for Quinoline. This does not mean that this substance is not harmful. Safe work practices should always be followed. It should be recognized that Quinoline can be absorbed through your skin, thereby increasing your exposure. * Quinoline is a MUTAGEN. Mutagens may have a cancer risk. All contact with this chemical should be reduced to the lowest possible level. WAYS OF REDUCING EXPOSURE * Where possible, enclose operations and use local exhaust ventilation at the site of chemical release. If local exhaust ventilation or enclosure is not used, respirators should be worn. * Wear protective work clothing. * Wash thoroughly immediately after exposure to Quinoline and at the end of the workshift. * Post hazard and warning information in the work area. In addition, as part of an ongoing education and training effort, communicate all information on the health and safety hazards of Quinoline to potentially exposed workers. This Fact Sheet is a summary source of information of all potential and most severe health hazards that may result from exposure. Duration of exposure, concentration of the substance and other factors will affect your susceptibility to any of the potential effects described below. ------------------------------------------ HEALTH HAZARD INFORMATION Acute Health Effects The following acute (short term) health effects may occur immediately or shortly after exposure to Quinoline: * Skin or eye contact can cause burns. * High exposures can cause nausea, vomiting, stomach pain, fever dizziness, fatigue, difficulty breathing and even death from paralysis of muscles needed for breathing. Liver damage may also occur. * The vapors can irritate the eyes, nose, throat and bronchial tubes and may cause sore throat, nosebleeds, hoarseness, cough, phlegm and/or tightness in the chest. High exposure could cause a dangerous fluid buildup in the lungs (pulmonary edema), a medical emergency. Chronic Health Effects The following chronic (long term) health effects can occur at some time after exposure to Quinoline and can last for months or years: Cancer Hazard * Quinoline causes MUTATIONS (genetic changes). Such chemicals may have a cancer or reproductive risk and in fact, there is limited evidence that Quinoline causes cancer in animals. It may cause cancer of the liver. Reproductive Hazard * According to the information presently available to the New Jersey Department of Health, Quinoline has not been tested for its ability to adversely affect reproduction. Other Long Term Effects * Repeated or high exposure can damage the retina of the eye (where nerves for vision are located, affecting vision). Earlier changes can go unnoticed without a complete exam. * Repeated exposure may damage the liver. * Exposure may lead to development of skin allergy, with rash and itching. (Direct irritation can also cause these effects). If allergy develops, even low future exposure could trigger rash. * Very irritating substances may affect the lungs. It is not known whether Quinoline causes lung damage. MEDICAL Medical Testing Before beginning employment and at regular times after that, the following are recommended: * Eye exam every 6 12 months, including complete vision testing and exam of the retina. * Lung function testing. If symptoms develop or overexposure is suspected, the following may also be useful: * Evaluation by a qualified allergist, including careful exposure history and special testing, may help diagnose skin allergy. * Consider chest x ray after acute overexposure. Any evaluation should include a careful history of past and present symptoms with an exam. Medical tests that look for damage already done are not a substitute for controlling exposure. Request copies of your medical testing. You have a legal right to this information under OSHA 1910.20. Mixed Exposures Because smoking can cause heart disease, as well as lung cancer, emphysema, and other respiratory problems, it may worsen respiratory conditions caused by chemical exposure. Even if you have smoked for a long time, stopping now will reduce your risk of developing health problems. WORKPLACE CONTROLS AND PRACTICES Unless a less toxic chemical can be substituted for a hazardous substance, ENGINEERING CONTROLS are the most effective way of reducing exposure. The best protection is to enclose operations and/or provide local exhaust ventilation at the site of chemical release. Isolating operations can also reduce exposure. Using respirators or protective equipment is less effective than the controls mentioned above, but is sometimes necessary. In evaluating the controls present in your workplace, consider: (1) how hazardous the substance is, (2) how much of the substance is released into the workplace and (3) whether harmful skin or eye contact could occur. Special controls should be in place for highly toxic chemicals or when significant skin, eye, or breathing exposures are possible. In addition, the following control is recommended: * Where possible, automatically pump liquid Quinoline from drums or other storage containers to process containers. Good WORK PRACTICES can help to reduce hazardous exposures. The following work practices are recommended: * Workers whose clothing has been contaminated by Quinoline should change into clean clothing promptly. * Contaminated work clothes should be laundered by individuals who have been informed of the hazards of exposure to Quinoline. * Eye wash fountains should be provided in the immediate work area for emergency use. * If there is the possibility of skin exposure, emergency shower facilities should be provided. * On skin contact with Quinoline, immediately wash or shower to remove the chemical. At the end of the workshift, wash any areas of the body that may have contacted Quinoline, whether or not known skin contact has occurred. * Do not eat, smoke, or drink where Quinoline is handled, processed, or stored, since the chemical can be swallowed. Wash hands carefully before eating or smoking. PERSONAL PROTECTIVE EQUIPMENT WORKPLACE CONTROLS ARE BETTER THAN PERSONAL PROTECTIVE EQUIPMENT. However, for some jobs (such as outside work, confined space entry, jobs done only once in a while, or jobs done while workplace controls are being installed), personal protective equipment may be appropriate. The following recommendations are only guidelines and may not apply to every situation. Clothing * Avoid skin contact with Quinoline. Wear protective gloves and clothing. Safety equipment suppliers/manufacturers can provide recommendations on the most protective glove/clothing material for your operation. * All protective clothing (suits, gloves, footwear, headgear) should be clean, available each day, and put on before work. Eye Protection * Wear splash proof chemical goggles and face shield when working with liquid, unless full facepiece respiratory protection is worn. Respiratory Protection IMPROPER USE OF RESPIRATORS IS DANGEROUS. Such equipment should only be used if the employer has a written program that takes into account workplace conditions, requirements for worker training, respirator fit testing and medical exams, as described in OSHA 1910.134. * Engineering controls must be effective to ensure that exposure to Quinoline does not occur. * Where the potential for exposure to Quinoline exists, use a MSHA/NIOSH approved supplied air respirator with a full facepiece operated in the positive pressure mode or with a full facepiece, hood, or helmet in the continuous flow mode, or use a MSHA/NIOSH approved self contained breathing apparatus with a full facepiece operated in pressure demand or other positive pressure mode. HANDLING AND STORAGE * Prior to working with Quinoline you should be trained on its proper handling and storage. * Quinoline is not compatible with STRONG OXIDIZERS (such as CHLORINE, BROMINE and FLUORINE), STRONG ACIDS (such as HYDROCHLORIC, SULFURIC and NITRIC), PERCHROMATES and NITROGEN TETROXIDE and STEAM. * Store in tightly closed containers in a cool, well ventilated area away from MOISTURE and LIGHT. * Sources of ignition, such as smoking and open flames, are prohibited where Quinoline is used, handled, or stored in a manner that could create a potential fire or explosion hazard. Common Name: Quinoline DOT Number: UN 2656 DOT Emergency Guide code: 29 CAS Number: 91-22-5 ---------------------------------------- NJ DOH Hazard rating FLAMMABILITY 1 REACTIVITY 0 ---------------------------------------- POISONOUS GASES ARE PRODUCED IN FIRE CONTAINERS MAY EXPLODE IN FIRE ---------------------------------------- Hazard Rating Key: 0=minimal; 1=slight; 2=moderate; 3=serious; 4=severe FIRE HAZARDS * Quinoline is a COMBUSTIBLE LIQUID. * Use dry chemical, CO2, water spray, or foam extinguishers. * POISONOUS GASES ARE PRODUCED IN FIRE, including Nitrogen Oxides, Carbon Monoxide and Carbon Dioxide. * Quinoline may burn, but does not readily ignite. * Vapors may travel to a source of ignition and flash back. * If employees are expected to fight fires, they must be trained and equipped as stated in OSHA 1910.156. SPILLS AND EMERGENCIES If Quinoline is spilled or leaked, take the following steps: * Restrict persons not wearing protective equipment from area of spill or leak until cleanup is complete. * Remove all ignition sources. * Ventilate area of spill or leak. * Absorb liquids in vermiculite, dry sand, earth, or a similar material and deposit in sealed containers. * It may be necessary to contain and dispose of Quinoline as a HAZARDOUS WASTE. Contact your state Environmental Program for specific recommendations. ========================================== FOR LARGE SPILLS AND FIRES immediately call your fire department. ========================================== FIRST AID POISON INFORMATION Eye Contact * Immediately flush with large amounts of water for at least 15 minutes, occasionally lifting upper and lower lids. Skin Contact * Quickly remove contaminated clothing. Immediately wash area with large amounts of soap and water. Seek medical attention promptly. Breathing * Remove the person from exposure. * Begin rescue breathing if breathing has stopped and CPR if heart action has stopped. * Transfer promptly to a medical facility. * Medical observation is recommended for 24 to 48 hours after breathing overexposure, as pulmonary edema may be delayed. PHYSICAL DATA Vapor Pressure: 1 mm Hg at 140oF (60oC) Flash Point: 214oF (101oC) Water Solubility: Soluble OTHER NAMES AND FORMULATIONS 1 Azanaphthalene; 1 Benzazine; Benzo(b) pyridine; Chinoline; Leucol; 1 Benzine. ------------------------------------------ Not intended to be copied and sold for commercial purposes. ------------------------------------------ NEW JERSEY DEPARTMENT OF HEALTH Right to Know Project CN 368, Trenton, NJ 08625 0368 ------------------------------------------ ------------------------------------------ ECOLOGICAL INFORMATION Quinoline is a colorless, hygroscopic liquid with a penetrating, pungent odor. It is used to make dyes, medicinal drugs, catalysts, ion-exchange polymers, herbicides, insecticides, corrosion inhibitors, antioxidants, and metallurgical chemicals; as a preservative for anatomical specimens, and as a solvent for resins and terpenes. It may enter the environment from industrial discharges or spills. ACUTE (SHORT-TERM) ECOLOGICAL EFFECTS Acute toxic effects may include the death of animals, birds, or fish, and death or low growth rate in plants. Acute effects are seen two to four days after animals or plants come in contact with a toxic chemical substance. Quinoline has moderate acute toxicity to aquatic life. Insufficient data are available to evaluate or predict the short-term effects of quinoline to plants, birds, or land animals. CHRONIC (LONG-TERM) ECOLOGICAL EFFECTS Chronic toxic effects may include shortened lifespan, reproductive problems, lower fertility, and changes in appearance or behavior. Chronic effects can be seen long after first exposure(s) to a toxic chemical. Quinoline has moderate chronic toxicity to aquatic life. Insufficient data are available to evaluate or predict the long- term effects of quinoline to plants, birds, and animals. WATER SOLUBILITY Quinoline is highly soluble in water. Concentrations of 1,000 milligrams and more will mix with a liter of water. DISTRIBUTION AND PERSISTENCE IN THE ENVIRONMENT Quinoline is moderately persistent in water, with a half-life between 20 to 200 days. The half-life of a pollutant is the amount of time it takes for one-half of the chemical to be degraded. About 88.7% of Quinoline will eventually end up in water; about 9.7% will end up in air; and the rest will be divided about equally between terrestrial soils and aquatic sediments. BIOACCUMULATION IN AQUATIC ORGANISMS Some substances increase in concentration, or bioaccumulate, in living organisms as they breathe contaminated air, drink contaminated water, or eat contaminated food. These chemicals can become concentrated in the tissues and internal organs of animals and humans. The concentration of Quinoline found in fish tissues is expected to be somewhat higher than the average concentration of Quinoline in the water from which the fish was taken. SUPPORT DOCUMENT: AQUIRE Database, ERL-Duluth, U.S. EPA.