Common Name: 5-Nitro-o-Anisidine CAS Number: 99-59-2 DOT Number: None Date: January, 1989 ----------------------------------------- HAZARD SUMMARY * 5-Nitro-o-Anisidine can affect you when breathed in and by passing through your skin. * 5-Nitro-o-Anisidine is a CARCINOGEN HANDLE WITH EXTREME CAUTION. * High exposure can interfere with the ability of the blood to carry oxygen to body organs (a condition called (methemoglobinemia). * Repeated exposure may affect the thyroid, liver and other organs. * Related chemicals can cause an allergic skin rash; irritate the throat and lungs; affect the kidneys, nervous system, adrenal gland and/or bone marrow. It is not known if 5-Nitro- o-Anisidine has any of these effects. IDENTIFICATION 5-Nitro-o-Anisidine is an orange to red needle like solid. It is used to make dyes and pigments. REASON FOR CITATION * 5-Nitro-o-Anisidine is on the Hazardous Substance List because it is cited by IARC, NTP, DEP and EPA. * This chemical is on the Special Health Hazard Substance List because it is a CARCINOGEN. * Definitions are attached. HOW TO DETERMINE IF YOU ARE BEING EXPOSED * Exposure to hazardous substances should be routinely evaluated. This may include collecting personal and area air samples. You can obtain copies of sampling results from your employer. You have a legal right to this information under OSHA 1910.20. * If you think you are experiencing any work related health problems, see a doctor trained to recognize occupational diseases. Take this Fact Sheet with you. WORKPLACE EXPOSURE LIMITS No occupational exposure limits have been established for 5-Nitro- o-Anisidine. This does not mean that this substance is not harmful. Safe work practices should always be followed. * It should be recognized that 5-Nitro-o-Anisidine can be absorbed through your skin, thereby increasing your expo sure. * 5-Nitro-o-Anisidine is a PROBABLE CARCINOGEN in humans. There may be no safe level of exposure to a carcinogen, so all contact should be reduced to the lowest possible level. WAYS OF REDUCING EXPOSURE * Where possible, enclose operations and use local exhaust ventilation at the site of chemical release. If local exhaust ventilation or enclosure is not used, respirators should be worn. * A regulated, marked area should be established where 5-Nitro- o-Anisidine is handled, used, or stored. * Wear protective work clothing. * Wash thoroughly immediately after exposure to 5-Nitro-o- Anisidine and at the end of the workshift. * Post hazard and warning information in the work area. In addition, as part of an ongoing education and training effort, communicate all information on the health and safety hazards of 5-Nitro-o-Anisidine to potentially exposed workers. This Fact Sheet is a summary source of information of all potential and most severe health hazards that may result from exposure. Duration of exposure, concentration of the substance and other factors will affect your susceptibility to any of the potential effects described below. ------------------------------------------ HEALTH HAZARD INFORMATION Acute Health Effects The following acute (short term) health effects may occur immediately or shortly after exposure to 5-Nitro-o-Anisidine: * High exposure can interfere with the ability of the blood to carry oxygen to body organs and can cause the skin to turn blue (a condition called methemoglobinemia). Chronic Health Effects The following chronic (long term) health effects can occur at some time after exposure to 5-Nitro-o-Anisidine and can last for months or years: Cancer Hazard * 5-Nitro-o-Anisidine is a PROBABLE CARCINOGEN in humans. There is some evidence that it causes skin, liver and reproductive organ cancers. * Many scientists believe there is no safe level of exposure to a carcinogen. Reproductive Hazard * There is limited evidence that 5-Nitro-o-Anisidine may damage the testes (male reproductive glands). Other Long Term Effects * Repeated exposure, especially at higher levels, may affect the liver, testes, thyroid and/or bone marrow. * Some related chemicals can cause one or more of these effects: reduced functioning of the adrenal gland, changes in the bile flow, allergic skin rash, kidney damage, nervous system effects, bone marrow damage and/or irritation of the nose, throat and lungs. It is not known whether 5-Nitro-o-Anisidine can cause any of these effects. MEDICAL Medical Testing If symptoms develop or overexposure is suspected, the following may be useful: * Test for methemoglobin (only accurate for a few hours after exposure). * Other tests depending on symptoms. Any evaluation should include a careful history of past and present symptoms with an exam. Medical tests that look for damage already done are not a substitute for controlling exposure. Request copies of your medical testing. You have a legal right to this information under OSHA 1910.20. WORKPLACE CONTROLS AND PRACTICES Unless a less toxic chemical can be substituted for a hazardous substance, ENGINEERING CONTROLS are the most effective way of reducing exposure. The best protection is to enclose operations and/or provide local exhaust ventilation at the site of chemical release. Isolating operations can also reduce exposure. Using respirators or protective equipment is less effective than the controls mentioned above, but is sometimes necessary. In evaluating the controls present in your workplace, consider: (1) how hazardous the substance is, (2) how much of the substance is released into the workplace and (3) whether harmful skin or eye contact could occur. Special controls should be in place for highly toxic chemicals or when significant skin, eye, or breathing exposures are possible. In addition, the following control is recommended: * Where possible, automatically transfer 5-Nitro-o-Anisidine from drums or other storage containers to process containers. Good WORK PRACTICES can help to reduce hazardous exposures. The following work practices are recommended: * Workers whose clothing has been contaminated by 5-Nitro-o- Anisidine should change into clean clothing promptly. * Do not take contaminated work clothes home. Family members could be exposed. * Contaminated work clothes should be laundered by individuals who have been informed of the hazards of exposure to 5-Nitro- o-Anisidine. * If there is the possibility of skin exposure, emergency shower facilities should be provided. * On skin contact with 5-Nitro-o-Anisidine, immediately wash or shower to remove the chemical. At the end of the workshift, wash any areas of the body that may have contacted 5-Nitro-o- Anisidine, whether or not known skin contact has occurred. * Do not eat, smoke, or drink where 5-Nitro-o-Anisidine is handled, processed, or stored, since the chemical can be swallowed. Wash hands carefully before eating or smoking. * Use a vacuum or a wet method to reduce dust during cleanup. DO NOT DRY SWEEP. * When vacuuming, a high efficiency particulate absolute (HEPA) filter should be used, not a standard shop vacuum. PERSONAL PROTECTIVE EQUIPMENT WORKPLACE CONTROLS ARE BETTER THAN PERSONAL PROTECTIVE EQUIPMENT. However, for some jobs (such as outside work, confined space entry, jobs done only once in a while, or jobs done while workplace controls are being installed), personal protective equipment may be appropriate. The following recommendations are only guidelines and may not apply to every situation. Clothing * Avoid skin contact with 5-Nitro-o-Anisidine. Wear protective gloves and clothing. Safety equipment suppliers/manufacturers can provide recommendations on the most protective glove/clothing material for your operation. * All protective clothing (suits, gloves, footwear, headgear) should be clean, available each day, and put on before work. Eye Protection * Eye protection is included in the recommended respiratory protection. Respiratory Protection IMPROPER USE OF RESPIRATORS IS DANGEROUS. Such equipment should only be used if the employer has a written program that takes into account workplace conditions, requirements for worker training, respirator fit testing and medical exams, as described in OSHA 1910.134. * Engineering controls must be effective to ensure that exposure to 5-Nitro-o-Anisidine does not occur. * At any exposure level, use a MSHA/NIOSH approved supplied air respirator with a full facepiece operated in the positive pressure mode or with a full facepiece, hood, or helmet in the continuous flow mode, or use a MSHA/NIOSH approved self contained breathing apparatus with a full facepiece operated in pressure demand or other positive pressure mode. Common Name: 5-Nitro-o-Anisidine DOT Number: None DOT Emergency Guide code: No Citation CAS Number: 99-59-2 ---------------------------------------- Hazard rating NJDOH NFPA FLAMMABILITY Not Found Not Rated REACTIVITY Not Found Not Rated ---------------------------------------- CARCINOGEN ---------------------------------------- Hazard Rating Key: 0=minimal; 1=slight; 2=moderate; 3=serious; 4=severe FIRE HAZARDS * Use dry chemical, CO2, water spray, or foam extinguishers. * If employees are expected to fight fires, they must be trained and equipped as stated in OSHA 1910.156. SPILLS AND EMERGENCIES If 5-Nitro-o-Anisidine is spilled take the following steps: * Restrict persons not wearing protective equipment from area of spill until cleanup is complete. * Collect powdered material in the most convenient and safe manner and deposit in sealed containers. * It may be necessary to contain and dispose of 5-Nitro-o- Anisidine as a HAZARDOUS WASTE. Contact your Department of Environmental Protection (DEP) or your regional office of the federal Environmental Protection Agency (EPA) for specific recommendations. ========================================== FOR LARGE SPILLS AND FIRES immediately call your fire department. ========================================== HANDLING AND STORAGE * Prior to working with 5-Nitro-o-Anisidine you should be trained on its proper handling and storage. * Store in tightly closed containers in a cool, well ventilated area. * A regulated, marked area should be established where 5-Nitro- o-Anisidine is handled, used, or stored. FIRST AID POISON INFORMATION Eye Contact * Immediately flush with large amounts of water for at least 15 minutes, occasionally lifting upper and lower lids. Skin Contact * Quickly remove contaminated clothing. Immediately wash contaminated skin with large amounts of soap and water. Breathing * Remove the person from exposure. * Begin rescue breathing if breathing has stopped and CPR if heart action has stopped. * Transfer promptly to a medical facility. PHYSICAL DATA Water Solubility: Slightly soluble OTHER COMMONLY USED NAMES Chemical Name: Benzenamine, 2 Methoxy 5 Nitro Other Names and Formulations: 2-Amino-4-Nitroanisole; Azoamine Scarlet K. ------------------------------------------ Not intended to be copied and sold for commercial purposes. ------------------------------------------ NEW JERSEY DEPARTMENT OF HEALTH Right to Know Program CN 368, Trenton, NJ 08625 0368 ----------------------------------------- ------------------------------------------ ECOLOGICAL INFORMATION 5-Nitro-o-Anisidine is a solid chemical, which may enter the environment from industrial discharges or spills. ACUTE (SHORT-TERM) ECOLOGICAL EFFECTS Acute toxic effects may include the death of animals, birds, or fish, and death or low growth rate in plants. Acute effects are seen two to four days after animals or plants come in contact with a toxic chemical substance. 5-Nitro-o-Anisidine has moderate acute toxicity to aquatic life and land animals, and high acute toxicity to birds. Insufficient data are available to evaluate or predict the short-term effects of 5- Nitro-o-Anisidine to plants. CHRONIC (LONG-TERM) ECOLOGICAL EFFECTS Chronic toxic effects may include shortened lifespan, reproductive problems, lower fertility, and changes in appearance or behavior. Chronic effects can be seen long after first exposure(s) to a toxic chemical. 5-Nitro-o-Anisidine has moderate chronic toxicity to aquatic life. Insufficient data are available to evaluate or predict the long- term effects of 5-Nitro-o-Anisidine to plants, birds, or land animals. WATER SOLUBILITY 5-Nitro-o-Anisidine is moderately soluble in water. Concentrations of between 1 to 1,000 milligrams will mix with a liter of water. DISTRIBUTION AND PERSISTENCE IN THE ENVIRONMENT 5-Nitro-o-Anisidine is slightly persistent in water, with a half- life of between 2 to 20 days. The half-life of a pollutant is the amount of time it takes for one-half of the chemical to be degraded. About 99.3% of 5-Nitro-o-Anisidine will eventually end up in water; the rest will be divided about equally among air, terrestrial soils, and aquatic sediments. BIOACCUMULATION IN AQUATIC ORGANISMS Some substances increase in concentration, or bioaccumulate, in living organisms as they breathe contaminated air, drink contaminated water, or eat contaminated food. These chemicals can become concentrated in the tissues and internal organs of animals and humans. The concentration of 5-Nitro-o-Anisidine found in fish tissues is expected to be about the same as the average concentration of 5- Nitro-o-Anisidine in the water from which the fish was taken. SUPPORT DOCUMENT: AQUIRE Database, ERL-Duluth, U.S. EPA. ÿÿ