Common Name: Maneb CAS Number: 12427-38-2 DOT Number: UN 2968 Date: February, 1988 ----------------------------------------- HAZARD SUMMARY * Maneb can affect you when breathed in. * Maneb should be handled as a CARCINOGEN WITH EXTREME CAUTION. * Overexposure can irritate the nose, throat and eyes. Repeated skin contact can cause rash. * High or repeated exposures may interfere with thyroid function, cause damage to the nervous system, affect liver function, or cause kidney damage. IDENTIFICATION Maneb is a yellow, odorless powder. It is a pesticide. REASON FOR CITATION * Maneb is on the Hazardous Substance List because it is cited by DOT, CAG DEP and EPA. * This chemical is on the Special Health Hazard Substance List because it is a CARCINOGEN. * Definitions are attached. HOW TO DETERMINE IF YOU ARE BEING EXPOSED * Exposure to hazardous substances should be routinely evaluated. This may include collecting personal and area air samples. You can obtain copies of sampling results from your employer. You have a legal right to this information under OSHA 1910.20. * If you think you are experiencing any work related health problems, see a doctor trained to recognize occupational diseases. Take this Fact Sheet with you. WORKPLACE EXPOSURE LIMITS No occupational exposure limits have been established for Maneb. This does not mean that this substance is not harmful. Safe work practices should always be followed. * Maneb may be a CARCINOGEN in humans. There may be no safe level of exposure to a carcinogen, so all contact should be reduced to the lowest possible level. WAYS OF REDUCING EXPOSURE * Where possible, enclose operations and use local exhaust ventilation at the site of chemical release. If local exhaust ventilation or enclosure is not used, respirators should be worn. * Wear protective work clothing. * Wash thoroughly at the end of the workshift. * Post hazard and warning information in the work area. In addition, as part of an ongoing education and training effort, communicate all information on the health and safety hazards of Maneb to potentially exposed workers. This Fact Sheet is a summary source of information of all potential and most severe health hazards that may result from exposure. Duration of exposure, concentration of the substance and other factors will affect your susceptibility to any of the potential effects described below. ------------------------------------------ HEALTH HAZARD INFORMATION Acute Health Effects The following acute (short term) health effects may occur immediately or shortly after exposure to Maneb: * Overexposure can irritate the eyes, nose, throat and bronchial tubes with sneezing, cough and phlegm. * Overexposure can damage the kidneys. Chronic Health Effects The following chronic (long term) health effects can occur at some time after exposure to Maneb and can last for months or years: Cancer Hazard * Maneb may be a CARCINOGEN in humans since it has been shown to cause lung cancer in animals. * Many scientists believe there is no safe level of exposure to a carcinogen. Such substances may also have the potential for causing reproductive damage in humans. Reproductive Hazard * There is limited evidence that Maneb is a teratogen in animals. Until further testing has been done, it should be treated as a possible teratogen in humans. * There is limited evidence that Maneb may decrease fertility in males and females. This effect appears to be reversible. Other Long Term Effects * Repeated overexposure can interfere with thyroid function and may cause goiter (enlarged thyroid gland). Damage to the nerves to the arms and legs may also occur, with tremors and loss of muscle strength. Personality changes may also occur. * Repeated skin contact can cause rash, usually from irritation. However, allergic rash can also develop. If this occurs, even low future exposures can cause rash. MEDICAL TESTING If symptoms develop or overexposure is suspected, the following may be useful: * Exam of the nervous system. * Thyroid function tests. * Consider kidney and liver function tests with higher exposures. Any evaluation should include a careful history of past and present symptoms with an exam. Medical tests that look for damage already done are not a substitute for controlling exposure. Request copies of your medical testing. You have a legal right to this information under OSHA 1910.20. WORKPLACE CONTROLS AND PRACTICES Unless a less toxic chemical can be substituted for a hazardous substance, ENGINEERING CONTROLS are the most effective way of reducing exposure. The best protection is to enclose operations and/or provide local exhaust ventilation at the site of chemical release. Isolating operations can also reduce exposure. Using respirators or protective equipment is less effective than the controls mentioned above, but is sometimes necessary. In evaluating the controls present in your workplace, consider: (1) how hazardous the substance is, (2) how much of the substance is released into the workplace and (3) whether harmful skin or eye contact could occur. Special controls should be in place for highly toxic chemicals or when significant skin, eye, or breathing exposures are possible. In addition, the following controls are recommended: * Specific engineering controls are recommended for this chemical by NIOSH. Refer to the NIOSH criteria document: Occupational Exposure during the Manufacture and Formulation of Pesticides #78 174. Good WORK PRACTICES can help to reduce hazardous exposures. The following work practices are recommended: * Workers whose clothing has been contaminated by Maneb should change into clean clothing promptly. * Do not take contaminated work clothes home. Family members could be exposed. * Contaminated work clothes should be laundered by individuals who have been informed of the hazards of exposure to Maneb. * On skin contact with Maneb, immediately wash or shower to remove the chemical. At the end of the workshift, wash any areas of the body that may have contacted Maneb, whether or not known skin contact has occurred. * Do not eat, smoke, or drink where Maneb is handled, processed, or stored, since the chemical can be swallowed. Wash hands carefully before eating or smoking. * Use a vacuum or a wet method to reduce dust during cleanup. DO NOT DRY SWEEP. PERSONAL PROTECTIVE EQUIPMENT WORKPLACE CONTROLS ARE BETTER THAN PERSONAL PROTECTIVE EQUIPMENT. However, for some jobs (such as outside work, confined space entry, jobs done only once in a while, or jobs done while workplace controls are being installed), personal protective equipment may be appropriate. The following recommendations are only guidelines and may not apply to every situation. Clothing * Avoid skin contact with Maneb. Wear protective gloves and clothing. Safety equipment suppliers/manufacturers can provide recommendations on the most protective glove/clothing material for your operation. * All protective clothing (suits, gloves, footwear, headgear) should be clean, available each day, and put on before work. Eye Protection * Wear dustproof goggles when working with powders or dust, unless full face piece respiratory protection is worn. Respiratory Protection IMPROPER USE OF RESPIRATORS IS DANGEROUS. Such equipment should only be used if the employer has a written program that takes into account workplace conditions, requirements for worker training, respirator fit testing and medical exams, as described in OSHA 1910.134. * Engineering controls must be effective to ensure that exposure to Maneb does not occur. * Where the potential exists for exposure to Maneb, use a MSHA/NIOSH approved supplied air respirator with a full facepiece operated in the positive pressure mode or with a full facepiece, hood, or helmet in the continuous flow mode, or use a MSHA/NIOSH approved self contained breathing apparatus with a full facepiece operated in pressure demand or other positive pressure mode. Common Name: Maneb DOT Number: UN 2968 DOT Emergency Guide code: 40 CAS Number: 12427-38-2 ---------------------------------------- NJ DOH Hazard rating FLAMMABILITY 1 REACTIVITY 2 ---------------------------------------- POISONOUS GASES ARE PRODUCED IN FIRE DO NOT USE WATER DANGEROUS WHEN WET ---------------------------------------- Hazard Rating Key: 0=minimal; 1=slight; 2=moderate; 3=serious; 4=severe FIRE HAZARDS * Use dry chemical, soda ash, or lime extinguishers. DO NOT USE WATER. * POISONOUS GASES ARE PRODUCED IN FIRE, including Nitrogen oxides, Hydrogen Sulfide, Sulfur oxides and Carbon Disulfide. * If employees are expected to fight fires, they must be trained and equipped as stated in OSHA 1910.156. SPILLS AND EMERGENCIES If Maneb is spilled or leaked, take the following steps: * Restrict persons not wearing protective equipment from area of spill or leak until clean up is complete. * Collect powdered material in the most convenient and safe manner and deposit in sealed containers. * Keep Maneb out of a confined space, such as a sewer, because of the possibility of an explosion, unless the sewer is designed to prevent the build up of explosive concentrations. * It may be necessary to contain and dispose of Maneb as a HAZARDOUS WASTE. Contact your state Environmental Program for specific recommendations. FOR LARGE SPILLS AND FIRES immediately call your fire department. HANDLING AND STORAGE * Prior to working with Maneb you should be trained on its proper handling and storage. * Maneb must be stored to avoid contact with WATER since violent reactions occur. * Store in tightly closed containers in a cool, well ventilated area away from ACIDS and OXIDIZING MATERIALS. FIRST AID POISON INFORMATION Eye Contact * Immediately flush with large amounts of water for at least 15 minutes, occasionally lifting upper and lower lids. Skin Contact * Remove contaminated clothing. Wash contaminated skin with soap and water. PHYSICAL DATA Water Solubility: Slightly soluble OTHER COMMONLY USED NAMES Chemical Name: Manganese, Ethylenebis (Dithiocarbamato) Other Names and Formulations: Manzate Maneb Fungicide; MEB; Sup R Flo; Unicrop Maneb; EBDC. ------------------------------------------ Not intended to be copied and sold for commercial purposes. ------------------------------------------ NEW JERSEY DEPARTMENT OF HEALTH Right to Know Program CN 368, Trenton, NJ 08625 0368 ------------------------------------------ ------------------------------------------ ECOLOGICAL INFORMATION Maneb is a yellow fungicidal powder. It is used for control of blights on potatoes and tomatoes; for control of other diseases in fruits, vegetables, and field crops; and as a turf fungicide. It may enter the environment from agricultural run-off, industrial discharges, or spills. ACUTE (SHORT-TERM) ECOLOGICAL EFFECTS Acute toxic effects may include the death of animals, birds, or fish, and death or low growth rate in plants. Acute effects are seen two to four days after animals or plants come in contact with a toxic chemical substance. Maneb has high acute toxicity to aquatic life and to birds. Insufficient data are available to evaluate or predict the short- term effects of maneb to plants or land animals. CHRONIC (LONG-TERM) ECOLOGICAL EFFECTS Chronic toxic effects may include shortened lifespan, reproductive problems, lower fertility, and changes in appearance or behavior. Chronic effects can be seen long after first exposure(s) to a toxic chemical. Maneb has high chronic toxicity to aquatic life. Insufficient data are available to evaluate or predict the long- term effects of maneb to plants, birds, or land animals. WATER SOLUBILITY Maneb is moderately soluble in water. Concentrations of between 1 to 1,000 milligrams will mix with a liter of water. DISTRIBUTION AND PERSISTENCE IN THE ENVIRONMENT Maneb does not hydrolyze in water, but it rapidly degrades in water under anaerobic (low or no oxygen) conditions. Ethylene thiourea is a major degradation product. Maneb probably sorbs to solids. BIOACCUMULATION IN AQUATIC ORGANISMS Some substances increase in concentration, or bioaccumulate, in living organisms as they breathe contaminated air, drink contaminated water, or eat contaminated food. These chemicals can become concentrated in the tissues and internal organs of animals and humans. The concentration of maneb found in fish tissues is expected to be somewhat higher than the average concentration of maneb in the water from which the fish was taken. SUPPORT DOCUMENT: AQUIRE Database, ERL-Duluth, U.S. EPA.