Common Name: o-Anisidine Hydrochloride CAS Number: 134-29-2 DOT Number: None Date: May, 1989 ----------------------------------------- HAZARD SUMMARY * o-Anisidine Hydrochloride can affect you when breathed in and by passing through your skin. * o-Anisidine Hydrochloride should be handled as a CARCINOGEN WITH EXTREME CAUTION. * Skin or eye contact can cause irritation or burns. * Exposure can interfere with the ability of the red blood cells to carry oxygen to body organs (methemoglobinemia), which can cause blue skin and lips at higher levels. * Repeated exposure can irritate the nose, throat and possibly lungs. Damage to the liver, spleen, kidney and thyroid may also occur, as well as anemia or other blood cell changes. * o-Anisidine Hydrochloride may cause a skin allergy. If allergy develops, very low future exposures can cause itching and a skin rash. IDENTIFICATION o-Anisidine Hydrochloride is a pale yellow to light reddish liquid. It is used as an intermediate in dye manufacturing. REASON FOR CITATION * o-Anisidine Hydrochloride is on the Hazardous Substance List because it is cited by NTP, IARC and EPA. * This chemical is on the Special Health Hazard Substance List because it is a CARCINOGEN. * Definitions are attached. HOW TO DETERMINE IF YOU ARE BEING EXPOSED * Exposure to hazardous substances should be routinely evaluated. This may include collecting personal and area air samples. You can obtain copies of sampling results from your employer. You have a legal right to this information under OSHA 1910.20. * If you think you are experiencing any work related health problems, see a doctor trained to recognize occupational diseases. Take this Fact Sheet with you. WORKPLACE EXPOSURE LIMITS The following exposure limits are for o-Anisidine. OSHA: The legal airborne permissible exposure limit (PEL) is 0.5 mg/m3 averaged over an 8 hour workshift. ACGIH: The recommended airborne exposure limit is 0.5 mg/m3 averaged over an 8 hour workshift. * o-Anisidine Hydrochloride may be a CARCINOGEN in humans. There may be no safe level of exposure to a carcinogen, so all contact should be reduced to the lowest possible level. * The above exposure limits are for air levels only. When skin contact also occurs, you may be overexposed, even though air levels are less than the limits listed above. WAYS OF REDUCING EXPOSURE * Where possible, enclose operations and use local exhaust ventilation at the site of chemical release. If local exhaust ventilation or enclosure is not used, respirators should be worn. * Wear protective work clothing. * Wash thoroughly immediately after exposure to o-Anisidine Hydrochloride and at the end of the workshift. * Post hazard and warning information in the work area. In addition, as part of an ongoing education and training effort, communicate all information on the health and safety hazards of o-Anisidine Hydrochloride to potentially exposed workers. This Fact Sheet is a summary source of information of all potential and most severe health hazards that may result from exposure. Duration of exposure, concentration of the substance and other factors will affect your susceptibility to any of the potential effects described below. ------------------------------------------ HEALTH HAZARD INFORMATION Acute Health Effects The following acute (short term) health effects may occur immediately or shortly after exposure to o-Anisidine Hydrochloride: * Contact can irritate or burn skin and eyes. * o-Anisidine Hydrochloride can interfere with the ability of red blood cells to carry oxygen to body organs (a condition called metheglobinemia). At higher levels this causes the lips and skin to turn blue. * The vapors irritate the nose, throat and lungs. Chronic Health Effects The following chronic (long term) health effects can occur at some time after exposure to o-Anisidine Hydrochloride and can last for months or years: Cancer Hazard * o-Anisidine Hydrochloride may be a CARCINOGEN in humans since it has been shown to cause urinary bladder in animals. * Many scientists believe there is no safe level of exposure to a carcinogen. Such substances may also have the potential for causing reproductive damage in humans. Reproductive Hazard * According to the information presently available to the New Jersey Department of Health, o-Anisidine Hydrochloride has not been tested for its ability to adversely affect reproduction. Other Long Term Effects * Repeated exposure may damage the liver, spleen, and kidneys and may cause anemia, or other blood cell changes. Changes in the lining of the womb may occur in women (endometrial hyperplasia). * o-Anisidine Hydrochloride may cause a skin allergy. If allergy develops, very low future exposures can cause itching and a skin rash. MEDICAL Medical Testing Before beginning employment and at regular times after that, the following are recommended: * Complete urine test; for abnormal cells (early cancer screening). * PAP tests (women). * Tests for kidney function. * Complete blood count. * Exam of the thyroid. * Evaluation by a qualified allergist, including careful exposure history and special testing, may help diagnose skin allergy. If symptoms develop or overexposure is suspected, the following may be useful: * Tests for methemoglobin; liver and kidney function. Any evaluation should include a careful history of past and present symptoms with an exam. Medical tests that look for damage already done are not a substitute for controlling exposure. Request copies of your medical testing. You have a legal right to this information under OSHA 1910.20. Mixed Exposures Smoking can also increase risk of bladder cancer; stopping smoking may reduce this risk. WORKPLACE CONTROLS AND PRACTICES respirators or protective equipment is less effective than the controls mentioned above, but is sometimes necessary. In evaluating the controls present in your workplace, consider: (1) how hazardous the substance is, (2) how much of the substance is released into the workplace and (3) whether harmful skin or eye contact could occur. Special controls should be in place for highly toxic chemicals or when significant skin, eye, or breathing exposures are possible. In addition, the following control is recommended: * Where possible, automatically pump liquid o-Anisidine Hydrochloride from drums or other storage containers to process containers. Good WORK PRACTICES can help to reduce hazardous exposures. The following work practices are recommended: * Workers whose clothing has been contaminated by o-Anisidine Hydrochloride should change into clean clothing promptly. * Do not take contaminated work clothes home. Family members could be exposed. * Contaminated work clothes should be laundered by individuals who have been informed of the hazards of exposure to o- Anisidine Hydrochloride. * Eye wash fountains should be provided in the immediate work area for emergency use. * If there is the possibility of skin exposure, emergency shower facilities should be provided. * On skin contact with o-Anisidine Hydrochloride, immediately wash or shower to remove the chemical. At the end of the workshift, wash any areas of the body that may have contacted o-Anisidine Hydrochloride, whether or not known skin contact has occurred. * Do not eat, smoke, or drink where o-Anisidine Hydrochloride is handled, processed, or stored, since the chemical can be swallowed. Wash hands carefully before eating or smoking. PERSONAL PROTECTIVE EQUIPMENT WORKPLACE CONTROLS ARE BETTER THAN PERSONAL PROTECTIVE EQUIPMENT. However, for some jobs (such as outside work, confined space entry, jobs done only once in a while, or jobs done while workplace controls are being installed), personal protective equipment may be appropriate. The following recommendations are only guidelines and may not apply to every situation. Clothing * Avoid skin contact with o-Anisidine Hydrochloride. Wear protective gloves and clothing. Safety equipment suppliers/manufacturers can provide recommendations on the most protective glove/ clothing material for your operation. * All protective clothing (suits, gloves, footwear, headgear) should be clean, available each day, and put on before work. Eye Protection * Eye protection is included in the recommended respiratory protection. Respiratory Protection IMPROPER USE OF RESPIRATORS IS DANGEROUS. Such equipment should only be used if the employer has a written program that takes into account workplace conditions, requirements for worker training, respirator fit testing and medical exams, as described in OSHA 1910.134. * At any exposure level, use a MSHA/NIOSH approved supplied air respirator with a full facepiece operated in the positive pressure mode or with a full facepiece, hood, or helmet in the continuous flow mode, or use a MSHA/NIOSH approved self contained breathing apparatus with a full facepiece operated in pressure demand or other positive pressure mode. Common Name: o-Anisidine Hydrochloride DOT Number: None DOT Emergency Guide code: No Citation CAS Number: 134-29-2 ---------------------------------------- Hazard rating NJ DOH NFPA FLAMMABILITY 1 Not Rated REACTIVITY 0 Not Rated ---------------------------------------- POISONOUS GASES ARE PRODUCED IN FIRE CARCINOGEN ---------------------------------------- Hazard Rating Key: 0=minimal; 1=slight; 2=moderate; 3=serious; 4=severe FIRE HAZARDS * POISONOUS GASES ARE PRODUCED IN FIRE, including Nitrogen Oxides and Hydrogenhloride. * Use alcohol foam extinquishers. Water or foam may cause frothing. * If employees are expected to fight fires, they must be trained and equipped as stated in OSHA 1910.156. SPILLS AND EMERGENCIES If o-Anisidine Hydrochloride is spilled or leaked, take the following steps: * Restrict persons not wearing protective equipment from area of spill or leak until cleanup is complete. * Remove all ignition sources. * Ventilate area of spill or leak. * Absorb liquids in vermiculite, dry sand, earth, or a similar material and deposit in sealed containers. * It may be necessary to contain and dispose of o-Anisidine Hydrochloride as a HAZARDOUS WASTE. Contact your state Environmental Program for specific recommendations. ========================================== FOR LARGE SPILLS AND FIRES immediately call your fire department. ========================================== HANDLING AND STORAGE * Prior to working with o-Anisidine Hydrochloride you should be trained on its proper handling and storage. * Store in tightly closed containers in a cool, well ventilated area. FIRST AID POISON INFORMATION Eye Contact * Immediately flush with large amounts of water for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. Skin Contact * Quickly remove contaminated clothing. Immediately wash contaminated skin with large amounts of soap and water. Breathing * Remove the person from exposure. * Begin rescue breathing if breathing has stopped and CPR if heart action has stopped. * Transfer promptly to a medical facility. * Effects of overexposure may be delayed; medical observation is recommended. OTHER COMMONLY USED NAMES Chemical Name: Benzenamine, 2 Methoxy, Hydrochloride Other Names and Formulations: Ortho Aminiosole Hydrochloride; 2 Anisidine Hydrochloride; 1 Amino 2 Methylbenzene Hydrochloride. ------------------------------------------ Not intended to be copied and sold for commercial purposes. ------------------------------------------ NEW JERSEY DEPARTMENT OF HEALTH Right to Know Program CN 368, Trenton, NJ 08625 0368 ------------------------------------------ ------------------------------------------ ECOLOGICAL INFORMATION o-Anisidine Hydrochloride is an acidified form of o-Anisidine which is used to make azo dyes. o-Anisidine Hydrochloride may enter the environment from industrial discharges or spills. ACUTE (SHORT-TERM) ECOLOGICAL EFFECTS Acute toxic effects may include the death of animals, birds, or fish, and death or low growth rate in plants. Acute effects are seen two to four days after animals or plants come in contact with a toxic chemical substance. o-Anisidine Hydrochloride will readily form o-Anisidine (CAS No. 90-04-0) and Hydrogen Chloride (CAS No. 7647-01-0) in water. o- Anisidine has moderate acute toxicity to aquatic life, while Hydrogen Chloride has slight acute toxicity to aquatic life. Consequently, o-Anisidine Hydrochloride has moderate acute toxicity to aquatic life. Insufficient data are available to evaluate or predict the short- term effects of o-Anisidine Hydrochloride to plants, birds, or land animals. CHRONIC (LONG-TERM) ECOLOGICAL EFFECTS Chronic toxic effects may include shortened lifespan, reproductive problems, lower fertility, and changes in appearance or behavior. Chronic effects can be seen long after first exposure(s) to a toxic chemical. o-Anisidine Hydrochloride has slight chronic toxicity to aquatic life. Insufficient data are available to evaluate or predict the long-term effects of o-Anisidine Hydrochloride to plants, birds, or land animals. DISTRIBUTION AND PERSISTENCE IN THE ENVIRONMENT o-Anisidine Hydrochloride will react rapidly with water to form o- anisidine and hydrochloric acid, and therefore will not persist in water. BIOACCUMULATION IN AQUATIC ORGANISMS Some substances increase in concentration, or bioaccumulate, in living organisms as they breathe contaminated air, drink contaminated water, or eat contaminated food. These chemicals can become concentrated in the tissues and internal organs of animals and humans. o-Anisidine Hydrochloride will react rapidly with water to form o- anisidine and hydrochloric acid, and therefore will not accumulate in aquatic organisms. SUPPORT DOCUMENT: AQUIRE Database, ERL-Duluth, U.S. EPA.