------------------------------------------------------------------------------ MSDS for COLCHICINE Page 1 ------------------------------------------------------------------------------ ------------------------------------------------------------------------------ 1 - PRODUCT IDENTIFICATION ------------------------------------------------------------------------------ PRODUCT NAME: COLCHICINE FORMULA: C22H25NO6 FORMULA WT: 399.45 CAS NO.: 00064-86-8 NIOSH/RTECS NO.: GH0700000 PRODUCT CODES: F784 EFFECTIVE: 12/01/86 REVISION #03 PRECAUTIONARY LABELLING BAKER SAF-T-DATA(TM) SYSTEM HEALTH - 3 SEVERE (POISON) FLAMMABILITY - 1 SLIGHT REACTIVITY - 0 NONE CONTACT - 2 MODERATE HAZARD RATINGS ARE 0 TO 4 (0 = NO HAZARD; 4 = EXTREME HAZARD). LABORATORY PROTECTIVE EQUIPMENT GOGGLES; LAB COAT; VENT HOOD; PROPER GLOVES PRECAUTIONARY LABEL STATEMENTS POISON DANGER HARMFUL IF INHALED MAY BE FATAL IF SWALLOWED CAUSES SEVERE IRRITATION DO NOT GET IN EYES, ON SKIN, ON CLOTHING. KEEP IN TIGHTLY CLOSED CONTAINER. WASH THOROUGHLY AFTER HANDLING. SAF-T-DATA(TM) STORAGE COLOR CODE: BLUE (HEALTH) ------------------------------------------------------------------------------ 2 - HAZARDOUS COMPONENTS ------------------------------------------------------------------------------ COMPONENT % CAS NO. COLCHICINE 90-100 64-86-8 ------------------------------------------------------------------------------ 3 - PHYSICAL DATA ------------------------------------------------------------------------------ BOILING POINT: N/A VAPOR PRESSURE(MM HG): N/A MELTING POINT: 142 C ( 288 F) VAPOR DENSITY(AIR=1): 14.0 SPECIFIC GRAVITY: N/A EVAPORATION RATE: N/A (H2O=1) (BUTYL ACETATE=1) ------------------------------------------------------------------------------ MSDS for COLCHICINE Page 2 ------------------------------------------------------------------------------ SOLUBILITY(H2O): MODERATE (1 TO 10 %) % VOLATILES BY VOLUME: 0 APPEARANCE & ODOR: PALE YELLOW SCALES OR POWDER WITH NO ODOR. ------------------------------------------------------------------------------ 4 - FIRE AND EXPLOSION HAZARD DATA ------------------------------------------------------------------------------ FLASH POINT (CLOSED CUP N/A FLAMMABLE LIMITS: UPPER - N/A % LOWER - N/A % FIRE EXTINGUISHING MEDIA USE WATER SPRAY, ALCOHOL FOAM, DRY CHEMICAL OR CARBON DIOXIDE. UNUSUAL FIRE & EXPLOSION HAZARDS CLOSED CONTAINERS EXPOSED TO HEAT MAY EXPLODE. ------------------------------------------------------------------------------ 5 - HEALTH HAZARD DATA ------------------------------------------------------------------------------ TOXICITY: LD50 (IPR-RAT)(MG/KG) - 6.1 LD50 (IV-RAT) (MG/KG) - 1.6 LD50 (SCU-MOUSE)(MG/KG) - 1.2 CARCINOGENICITY: NTP: NO IARC: NO Z LIST: NO OSHA REG: NO EFFECTS OF OVEREXPOSURE DUST MAY BE IRRITATING TO EYES, NOSE, THROAT, OR LUNGS. INHALATION OF DUST MAY CAUSE HEADACHE, NAUSEA, VOMITING, SHORTNESS OF BREATH, OR BLURRED VISION. CONTACT WITH SKIN OR EYES MAY CAUSE SEVERE IRRITATION OR BURNS. INGESTION MAY CAUSE NAUSEA, VOMITING, GASTROINTESTINAL IRRITATION, AND BURNS TO MOUTH AND THROAT. CHRONIC EFFECTS OF OVEREXPOSURE MAY INCLUDE KIDNEY AND/OR LIVER DAMAGE. TARGET ORGANS EYES, SKIN MEDICAL CONDITIONS GENERALLY AGGRAVATED BY EXPOSURE NONE IDENTIFIED ROUTES OF ENTRY INHALATION, INGESTION, ABSORPTION, EYE CONTACT, SKIN CONTACT EMERGENCY AND FIRST AID PROCEDURES CALL A PHYSICIAN. IF SWALLOWED, IF CONSCIOUS, IMMEDIATELY INDUCE VOMITING. IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING, GIVE ARTIFICIAL RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN. IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES OR SKIN WITH PLENTY OF WATER FOR AT LEAST 15 MINUTES. ------------------------------------------------------------------------------ 6 - REACTIVITY DATA ------------------------------------------------------------------------------ ------------------------------------------------------------------------------ MSDS for COLCHICINE Page 3 ------------------------------------------------------------------------------ STABILITY: STABLE HAZARDOUS POLYMERIZATION: WILL NOT OCCUR CONDITIONS TO AVOID: LIGHT ------------------------------------------------------------------------------ 7 - SPILL AND DISPOSAL PROCEDURES ------------------------------------------------------------------------------ STEPS TO BE TAKEN IN THE EVENT OF A SPILL OR DISCHARGE WEAR SELF-CONTAINED BREATHING APPARATUS AND FULL PROTECTIVE CLOTHING. WITH CLEAN SHOVEL, CAREFULLY PLACE MATERIAL INTO CLEAN, DRY CONTAINER AND COVER; REMOVE FROM AREA. FLUSH SPILL AREA WITH WATER. DISPOSAL PROCEDURE DISPOSE IN ACCORDANCE WITH ALL APPLICABLE FEDERAL, STATE, AND LOCAL ENVIRONMENTAL REGULATIONS. ------------------------------------------------------------------------------ 8 - PROTECTIVE EQUIPMENT ------------------------------------------------------------------------------ VENTILATION: USE ADEQUATE GENERAL OR LOCAL EXHAUST VENTILATION TO KEEP FUME OR DUST LEVELS AS LOW AS POSSIBLE. RESPIRATORY PROTECTION: NONE REQUIRED WHERE ADEQUATE VENTILATION CONDITIONS EXIST. IF AIRBORNE CONCENTRATION IS HIGH, A CHEMICAL CARTRIDGE RESPIRATOR WITH ORGANIC VAPOR CARTRIDGE IS RECOMMENDED. IF CONCENTRATION EXCEEDS CAPACITY OF CARTRIDGE RESPIRATOR, A SELF- CONTAINED BREATHING APPARATUS IS ADVISED. EYE/SKIN PROTECTION: SAFETY GOGGLES, UNIFORM, APRON, PROPER GLOVES ARE RECOMMENDED. ------------------------------------------------------------------------------ 9 - STORAGE AND HANDLING PRECAUTIONS ------------------------------------------------------------------------------ SAF-T-DATA(TM) STORAGE COLOR CODE: BLUE (HEALTH) SPECIAL PRECAUTIONS KEEP CONTAINER TIGHTLY CLOSED. STORE IN SECURE POISON AREA. KEEP PRODUCT OUT OF LIGHT. ------------------------------------------------------------------------------ 10 - TRANSPORTATION DATA AND ADDITIONAL INFORMATION ------------------------------------------------------------------------------ DOMESTIC (D.O.T.) PROPER SHIPPING NAME POISON B SOLID, N.O.S. (COLCHICINE) HAZARD CLASS POISON B LABELS POISON INTERNATIONAL (I.M.O.) PROPER SHIPPING NAME ALKALOIDS, POISONOUS, N.O.S. (COLCHICINE) ------------------------------------------------------------------------------ MSDS for COLCHICINE Page 4 ------------------------------------------------------------------------------ HAZARD CLASS 6.1 UN/NA UN1544 LABELS POISON